39 Result(s)

Article

Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report

This study aimed to determine the retest variability of quantitative fundus autofluorescence (QAF) in patients with and without age-related macular degeneration (AMD) and evaluate the predictive value of patie...

Leon von der Emde, Merten Mallwitz, Marc Vaisband, Jan Hasenauer… in Scientific Reports (2023)

Article

Blue-light fundus autofluorescence imaging of pigment epithelial detachments

Pigment epithelial detachments (PEDs) occur in association with various chorioretinal diseases. With respect to the broad clinical spectrum of PEDs we describe fundus autofluorescence (FAF) characteristics of ...

Almut Bindewald-Wittich, Joanna Dolar-Szczasny, Sandrine H. Kuenzel… in Eye (2023)

Article

Author Correction: Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Davide Garzone, Jan Henrik Terheyden, Olivier Morelle… in Scientific Reports (2023)

Article

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT device...

Davide Garzone, Jan Henrik Terheyden, Olivier Morelle… in Scientific Reports (2022)

Article

Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy

Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we assessed the association of ...

Maximilian Pfau, Steffen Schmitz-Valckenberg, Ramiro Ribeiro… in Scientific Reports (2022)

Article

Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the...

Marlene Saßmannshausen, Charlotte Behning, Ben Isselmann… in Scientific Reports (2022)

Article

A randomized, open-label, multicenter study of switching to brolucizumab with or without a loading dose for patients with suboptimal anatomically controlled neovascular age-related macular degeneration—the FALCON study

Treatment initiation with brolucizumab, a new potent anti-vascular endothelial growth factor (VEGF) agent, is typically performed with three monthly injections (loading dose) and has been well studied in treat...

F. G. Holz, Steffen Schmitz-Valckenberg… in Graefe's Archive for Clinical and Experime… (2022)

Article

Estimation of current and post-treatment retinal function in chronic central serous chorioretinopathy using artificial intelligence

Refined understanding of the association of retinal microstructure with current and future (post-treatment) function in chronic central serous chorioretinopathy (cCSC) may help to identify patients that would ...

Maximilian Pfau, Elon H. C. van Dijk, Thomas J. van Rijssen… in Scientific Reports (2021)

Article

Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

To model the progression of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) by building a suitable statistical regression model for GA size measurements obtained from fundus aut...

Charlotte Behning, Monika Fleckenstein, Maximilian Pfau… in BMC Medical Research Methodology (2021)

Article

AI-based structure-function correlation in age-related macular degeneration

Sensitive and robust outcome measures of retinal function are pivotal for clinical trials in age-related macular degeneration (AMD). A recent development is the implementation of artificial intelligence (AI) t...

Leon von der Emde, Maximilian Pfau, Frank G. Holz, Monika Fleckenstein… in Eye (2021)

Article

Author Correction: Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

Maximilian W. M. Wintergerst, Shekoufeh Gorgi Zadeh, Vitalis Wiens… in Scientific Reports (2021)

Article

Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration

To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had ...

Yaniv Barkana, Susanne G. Pondorfer, Steffen Schmitz-Valckenberg… in Scientific Reports (2021)

Article

Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration develo** novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention—MACUSTAR

There is an unmet need for treatment options in intermediate age-related macular degeneration (iAMD). However, for any new interventions to be tested in clinical trials, novel currently unavailable clinical en...

Jan H. Terheyden, Frank G. Holz, Steffen Schmitz-Valckenberg, Anna Lüning… in Trials (2020)

Article

Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined tha...

Maximilian W. M. Wintergerst, Shekoufeh Gorgi Zadeh, Vitalis Wiens… in Scientific Reports (2020)