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Article
OPA1, associated with autosomal dominant optic atrophy, is widely expressed in the human brain
Autosomal dominant optic atrophy (adOA) is the most prevalent hereditary optic neuropathy with moderate to severe visual field loss and loss of retinal ganglion cells. The majority of cases of adOA is associat...
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Article
OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear
Autosomal dominant optic atrophy (adOA) is the most common form of hereditary optic neuropathy. The majority of cases are associated with mutations in the OPA1 gene. A few cases of adOA are known to be associated...
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Article
Sequences of the Non-Coding RNA, NTAB, are Contained within the 3′-UTR of Human and Rat EAAT2/GLT-1 Transcripts and Act as Transcriptional Enhancers
In the CNS, extracellular glutamate is predominantly cleared by astroglial cells through the high-affinity glutamate transporter subtype, EAAT2/GLT-1. Expression of EAAT2/GLT-1 is perturbed in various acute an...
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Article
Transcriptional Regulation of the GLAST/EAAT-1 Gene in Rat and Man
Various acute and chronic brain diseases result in disturbed expression of the glial glutamate transporters, GLAST/EAAT-1 and GLT-1/EAAT-2, and subsequent secondary neuronal cell death. The idea that glutamate...
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Article
Textural analysis of pre-therapeutic [18F]-FET-PET and its correlation with tumor grade and patient survival in high-grade gliomas
Amino acid positron emission tomography (PET) with [18F]-fluoroethyl-L-tyrosine (FET) is well established in the diagnostic work-up of malignant brain tumors. Analysis of FET-PET data using tumor-to-background...
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Article
Positron emission tomography and magnetic resonance spectroscopy in cerebral gliomas
Conventional MRI, the gold standard in structural brain imaging, alone has its limitations in pre-operative tumour grading, biopsy targeting, determination of accurate tumour margins prior to surgical resectio...
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Article
Open AccessDoes age really matter? Radiotherapy in elderly patients with glioblastoma, the Munich experience
Glioblastoma is usually diagnosed around the age of 60–70 years. Patients older than 65 years are frequently described as “elderly”. Several trials with monotherapy have established treatment regimens that off...
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Article
Open AccessSafe Brain Tumor Resection Does not Depend on Surgery Alone - Role of Hemodynamics
Aim of this study was to determine if perioperative hemodynamics have an impact on perioperative infarct volume and patients’ prognosis. 201 cases with surgery for a newly diagnosed or recurrent glioblastoma w...
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Article
Open AccessImpact of ischemic preconditioning on surgical treatment of brain tumors: a single-center, randomized, double-blind, controlled trial
Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Particularly in the field of cardiac and ...
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Article
Open AccessDiffusion tensor image features predict IDH genotype in newly diagnosed WHO grade II/III gliomas
We hypothesized that machine learning analysis based on texture information from the preoperative MRI can predict IDH mutational status in newly diagnosed WHO grade II and III gliomas. This retrospective study in...
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Article
Open AccessFactors influencing neurocognitive function in patients with neuroepithelial tumors
Though cognitive function is proven to be an independent predictor of survival in patients with intrinsic brain tumors, cognitive functions are still rarely considered. Aim of this study was to assess neurocog...
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Article
Open AccessPublisher Correction: Factors influencing neurocognitive function in patients with neuroepithelial tumors
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessRetrospective Analysis of Radiological Recurrence Patterns in Glioblastoma, Their Prognostic Value And Association to Postoperative Infarct Volume
Recent studies suggested that postoperative hypoxia might trigger invasive tumor growth, resulting in diffuse/multifocal recurrence patterns. Aim of this study was to analyze distinct recurrence patterns and t...
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Article
Open AccessPersonality Traits in Patients with Neuroepithelial Tumors – A Prospective Study
Aim of this study was to analyze personality traits in patients with neuroepithelial brain tumors. Personality alteration is a common feature in brain tumor patients, but not much is known about associations b...
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Article
Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors
Parameter maps based on wavelet-transform post-processing of dynamic perfusion data offer an innovative way of visualizing blood vessels in a fully automated, user-independent way. The aims of this study were ...
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Article
Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma
The aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients.
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Article
Open AccessRisk factors for neurocognitive impairment in patients with benign intracranial lesions
This study was designed to assess risk factors for neurocognitive impairment in patients with benign intracranial lesions including tumors and vascular lesions. 74 patients (29 m, 51 f, mean age 54.4 years) wi...
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Article
MRI criteria of subtypes of adenomas and epithelial cysts of the pituitary gland
This study aimed to assess the clinical applicability of MRI criteria for differentiation of pituitary adenomas and cystic pituitary lesions. One hundred ninety-eight consecutive patients with surgical resecti...
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Article
Perioperative neurocognitive functions in patients with neuroepithelial intracranial tumors
This study aimed to assess perioperative neurocognitive functions in patients with surgery for intracranial neuroepithelial tumors.
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Article
Open AccessPostoperative cognitive functions in patients with benign intracranial lesions
The aim of this study was to assess pre- and postoperative cognitive functions in patients who underwent surgery for benign intracranial lesions. In total, 58 patients (21 men, 37 women, mean age 51.6 years [r...
