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Open AccessRisk factors for preterm birth: an umbrella review of meta-analyses of observational studies
Preterm birth defined as delivery before 37 gestational weeks is a leading cause of neonatal and infant morbidity and mortality. The aim of this study is to summarize the evidence from meta-analyses of observa...
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Article
Prenatal exposure to ambient particle radioactivity and fetal growth in Eastern Massachusetts
The radioactive component of particulate matter (PM), particle radioactivity (PR), can continue to emit radiation after inhalation. While PR has been associated with other adverse pregnancy outcomes, no studie...
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Article
Prenatal exposure to wildfire-related air pollution and birth defects in Brazil
Birth defects are a major cause of poor health outcomes during both childhood and adulthood. A growing body of evidence demonstrated associations between air pollution exposure during pregnancy and birth defec...
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Article
Open AccessThe effect of diabetes on surgical versus percutaneous left main revascularization outcomes: a systematic review and meta-analysis
The optimal method of coronary revascularization for diabetes mellitus (DM) patients with left main coronary artery disease (LMCAD) is controversial in the drug-eluting stent (DES) era.
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Article
Association between omentin-1 and indices of glucose metabolism in early pregnancy: a pilot study
Omentin-1 plays an important role in regulating insulin sensitivity outside pregnancy. As an adipokine derived from human placental and adipose tissue, it may be an important contributor in the biological path...
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Air Quality and Health Impacts
Associations between air pollution and overall morbidity and mortality have long been identified in Europe. Epidemiological studies have shown that there is an increased risk of cardiovascular and respiratory ...
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Article
Open AccessAmbient PM gross β-activity and glucose levels during pregnancy
Exposure to ionizing radiation has been associated with insulin resistance and type 2 diabetes. In light of recent work showing an association between ambient particulate matter (PM) gross β-activity and gesta...
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Article
Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric and adult population: a systematic review and meta-analysis
Treatment options for hydrocephalus include endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS). Some ambiguity remains regarding indications, safety, and efficacy for these procedures ...
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Article
Open AccessEffectiveness of corticosteroids for post-extubation stridor and extubation failure in pediatric patients: a systematic review and meta-analysis
While the results of previous meta-analyses have shown beneficial effects of corticosteroid therapy on post-extubation stridor and extubation failure in adults, these results might not be generalizable to chil...
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Article
Open AccessThe relationship between physical activity and lymphoma: a systematic review and meta analysis
The literature suggests an increased risk between anthropometrics including higher body mass index and lymphoma incidence; however, the association with physical activity remains unclear. A systematic review/m...
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Article
Enhanced oral hygiene interventions as a risk mitigation strategy for the prevention of non-ventilator-associated pneumonia: a systematic review and meta-analysis
Background Healthcare-acquired pneumonias are a significant risk for nursing home and hospital patients. While oral care interventions (OCIs) have been found to be effective in reducing the risk of ventilator-as...
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Article
The Safety and Efficacy of Tranexamic Acid in Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis
Major spinal corrective surgeries can be associated with critical intra-operative blood loss. The objective of this systematic review and meta-analysis was to assess the safety and efficacy of tranexamic acid ...
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Author Reply: A critical reflection on the grading of the certainty of evidence in umbrella reviews
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Umbrella reviews: what they are and why we need them