3 Result(s)

Article

Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells

Karin Belander Strålin, Joana Carrelha, Axel Winroth, Christoph Ziegenhain… in Cell Research (2023)

Article

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Acute myeloid leukemia (AML), the most frequent leukemia in adults, is driven by recurrent somatically acquired genetic lesions in a restricted number of genes. Treatment with tyrosine kinase inhibitors has de...

Eirini Giannakopoulou, Madeleine Lehander, Stina Virding Culleton… in Nature Cancer (2023)

Article

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific fo...

Muhammad Ali, Eirini Giannakopoulou, Yingqian Li… in Nature Biotechnology (2022)