5 Result(s)

Article

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells

Rare multipotent stem cells replenish millions of blood cells per second through a time-consuming process, passing through multiple stages of increasingly lineage-restricted progenitors. Although insults to th...

Joana Carrelha, Stefania Mazzi, Axel Winroth, Michael Hagemann-Jensen… in Nature Immunology (2024)

Article

Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells

Karin Belander Strålin, Joana Carrelha, Axel Winroth, Christoph Ziegenhain… in Cell Research (2023)

Article

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Acute myeloid leukemia (AML), the most frequent leukemia in adults, is driven by recurrent somatically acquired genetic lesions in a restricted number of genes. Treatment with tyrosine kinase inhibitors has de...

Eirini Giannakopoulou, Madeleine Lehander, Stina Virding Culleton… in Nature Cancer (2023)

Article

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner

Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to differen...

Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini… in Nature Communications (2023)

Article

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific fo...

Muhammad Ali, Eirini Giannakopoulou, Yingqian Li… in Nature Biotechnology (2022)