52 Result(s)

Article

Can docetaxel plus estramustine prolong survival of men with metastatic hormone-refractory prostate cancer?

Stefan Sleijfer, Gerrit Stoter in Nature Clinical Practice Oncology (2005)

Article

Side Effects of Interferon-α Therapy

Interferon-α (IFN-α) has been extensively explored for its efficacy in various disease conditions and is currently used as a standard treatment in several of these. Its use is accompanied by a wide variety of pos...

Stefan Sleijfer, Marjolein Bannink, Arthur R. Van Gool… in Pharmacy World and Science (2005)

Chapter

GIST As the Model of Paradigm Shift Towards Targeted Therapy of Solid Tumors: Update and Perspective on Trial Design

Gastrointestinal Stroma Tumors — or GIST — are the most common gastrointestinal (GI) sarcomas, and were only recently identified as a distinct clinical and histopathologic entity (Corless, Fletcher and Heinric...

Jaap Verweij, Caroline Seynaeve, Stefan Sleijfer in Targeted Therapies in Cancer (2008)

Article

Drug Insight: gastrointestinal stromal tumors (GIST)—the solid tumor model for cancer-specific treatment

Steady progress has been made in our understanding of the pathogenesis of gastrointestinal stromal tumors (GIST). The tyrosine kinas inhibitor, imatinib, exhibits impressive anti-tumor effects against GIST and...

Stefan Sleijfer, Erik Wiemer, Jaap Verweij in Nature Clinical Practice Oncology (2008)

Article

Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer

Purpose In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy. The ...

Maurice P. H. M. Jansen, Kirsten Ruigrok-Ritstier… in Breast Cancer Research and Treatment (2009)

Article

Adjuvant chemotherapy in older patients with breast cancer

A prospective, randomized trial has shown that standard adjuvant chemotherapy is superior to capecitabine in the treatment of women with breast cancer aged 65 years or older; on the basis of the results of thi...

Agnes Jager, Jaap Verweij, Stefan Sleijfer in Nature Reviews Clinical Oncology (2009)

Article

Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR

Detection of circulating tumor cells (CTCs) in whole blood from metastatic cancer patients by the CellSearch™ CTC Test (Veridex LLC, Warren, NJ, USA) has been shown to have clinical relevance. In addition to e...

Anieta M. Sieuwerts, Jaco Kraan, Joan Bolt-de Vries… in Breast Cancer Research and Treatment (2009)

Article

Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146

Most assays to detect circulating tumor cells (CTCs) rely on EpCAM expression on tumor cells. Recently, our group reported that in contrast to other molecular breast cancer subtypes, “normal-like” cell lines l...

Bianca Mostert, Jaco Kraan, Joan Bolt-de Vries… in Breast Cancer Research and Treatment (2011)

Article

MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer

MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. We evaluated whether five candidate predictive miRNAs, derived from a pilot study in which 249...

F. Germán Rodríguez-González, Anieta M. Sieuwerts… in Breast Cancer Research and Treatment (2011)

Article

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes

One of the hallmarks of human solid tumors is chromosomal instability (CIN). We studied global patterns as well as individual levels of CIN and determined the prognostic relevance among breast cancer subtypes....

Marcel Smid, Marlous Hoes, Anieta M. Sieuwerts… in Breast Cancer Research and Treatment (2011)

Article

Clinical value of circulating tumor cells in breast cancer

In a trial in patients with metastatic breast cancer, the prognostic value of the number of circulating tumor cells (CTCs) at baseline was independent of tumor subtype, except in patients with HER2-positive di...

Stefan Sleijfer, John A. Foekens in Nature Reviews Clinical Oncology (2011)

Article

Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes

To understand the biology of low-risk breast cancer alleles, and to investigate whether these loci also contribute to disease progression that was once established, we examined the association of SNPs tagging ...

Muhammad Riaz, Els M. J. J. Berns… in Breast Cancer Research and Treatment (2012)

Article

Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen

PIK3CA mutations occur frequently in breast cancer, predominantly in exons 9 and 20. The aim of this retrospective study is to evaluate the PIK3CA mutation status for its relationship with progno...

Diana E. Ramirez-Ardila, Jean C. Helmijr… in Breast Cancer Research and Treatment (2013)