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Article
Open AccessIndependent validation of CT radiomics models in colorectal liver metastases: predicting local tumour progression after ablation
Independent internal and external validation of three previously published CT-based radiomics models to predict local tumor progression (LTP) after thermal ablation of colorectal liver metastases (CRLM).
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Article
Open AccessGenomic characterization and detection of potential therapeutic targets for peritoneal mesothelioma in current practice
Peritoneal mesothelioma (PeM) is an aggressive tumor with limited treatment options. The current study aimed to evaluate the value of next generation sequencing (NGS) of PeM samples in current practice. Founda...
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Article
Open AccessAssessing patients’ needs in the follow-up after treatment for colorectal cancer—a mixed-method study
The accessibility of cancer care faces challenges due to the rising prevalence of colorectal cancer (CRC) coupled with a shrinkage of healthcare professionals—known as the double aging phenomenon. To ensure su...
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Article
Open AccessHistopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases
Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunot...
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Article
Open AccessDeep learning models for automatic tumor segmentation and total tumor volume assessment in patients with colorectal liver metastases
We developed models for tumor segmentation to automate the assessment of total tumor volume (TTV) in patients with colorectal liver metastases (CRLM).
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Article
Open AccessUptake of robot-assisted colon cancer surgery in the Netherlands
The robot-assisted approach is now often used for rectal cancer surgery, but its use in colon cancer surgery is less well defined. This study aims to compare the outcomes of robotic-assisted colon cancer surge...
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Article
Open AccessSurgical treatment and overall survival in patients with right-sided obstructing colon cancer—a nationwide retrospective cohort study
The aim of this study was to compare baseline characteristics, 90-day mortality and overall survival (OS) between patients with obstructing and non-obstructing right-sided colon cancer at a national level.
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Article
Open AccessTowards patient-led follow-up after curative surgical resection of stage I, II and III colorectal cancer (DISTANCE-trial): a study protocol for a stepped-wedge cluster-randomised trial
Colorectal cancer (CRC) is among the most frequently diagnosed cancers. Approximately 20–30% of stage I-III CRC patients develop a recurrent tumour or metastases after curative surgical resection. Post-operati...
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Article
Open AccessQuantification of indocyanine green near-infrared fluorescence bowel perfusion assessment in colorectal surgery
Indocyanine green near-infrared fluorescence bowel perfusion assessment has shown its potential benefit in preventing anastomotic leakage. However, the surgeon's subjective visual interpretation of the fluores...
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Article
Open AccessPrimary tumor resection or systemic treatment as palliative treatment for patients with isolated synchronous colorectal cancer peritoneal metastases in a nationwide cohort study
Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options for patients with isolated synchronous colorectal cancer peritoneal meta...
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Article
Open AccessPreoptimisation in patients with acute obstructive colon cancer (PREOCC) – a prospective registration study protocol
Postoperative mortality and morbidity rates are high in patients with obstructing colon cancer (OCC). Different treatment options have been evaluated over the years, mainly for left sided OCC. Optimising the p...
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Article
Open AccessIntraperitoneal Chemotherapy for Unresectable Peritoneal Surface Malignancies
Malignancies of the peritoneal cavity are associated with a dismal prognosis. Systemic chemotherapy is the gold standard for patients with unresectable peritoneal disease, but its intraperitoneal effect is ham...
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Article
Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further su...
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Article
Open AccessThe relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases
The histopathological growth patterns (HGPs) are a prognostic and predictive biomarker in colorectal cancer liver metastasis (CRLM). This study evaluates the relationship between the HGP and primary colorectal...
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Article
Open AccessCorrection: Quality of life of caregivers of breast cancer patients: a cross-sectional evaluation
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Article
Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter study
Distinct Histopathological Growth Patterns can be identified in liver metastases from melanoma, breast and colorectal cancers. For each of these distinct liver metastasis types the HGP has proven a biomarker f...
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Article
Open AccessDifferential Diagnosis and Molecular Stratification of Gastrointestinal Stromal Tumors on CT Images Using a Radiomics Approach
Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs’ molecular analysis. The aim of this study was to evaluate radiomics for ...
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Article
Open AccessQuality of life of caregivers of breast cancer patients: a cross-sectional evaluation
The aim of this study was to evaluate the care-related quality of life in caregivers of breast cancer patients, to assess its association with breast cancer patients’ health-related quality of life (HRQoL), an...
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Article
Open AccessDiagnostic value of 18F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients
Detecting malignant peripheral nerve sheath tumors (MPNSTs) remains difficult. 18F-FDG PET-CT has been shown helpful, but ideal threshold values of semi-quantitative markers remain unclear, partially because of v...
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Article
Open AccessDisease recurrence after colorectal cancer surgery in the modern era: a population-based study
This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatme...
