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Article
Open AccessMEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by asbestos exposure, for which there are few effective treatment options. Although asbestos carcinogenesis is associated with r...
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Article
Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism
Age and gender are the important factors for brain metabolic declines in both normal aging and neurodegeneration, and the confounding effects may influence early and differential diagnosis of neurodegenerative...
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Chapter
Introducing the Ecological Aspects
Combined results from both the BACOSA and SECOS projects highlight structure and function of aquatic Baltic Sea ecosystems in a gradient from land to open Sea.
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Chapter
Patterns of Bioturbation and Associated Matter Fluxes
Bioturbation, the biogenic particle and fluid transport in sediments, is generally thought to be important in the context of matter fluxes and therefore ecosystem functions. This chapter summarizes current kno...
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Chapter
Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea
Situated in a gradient from land to the open sea, coastal water bodies can be separated into outer coastal waters and inner coastal waters. The southern Baltic Sea shows mostly lagoon-like coastal waters. Thou...
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Chapter
Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain
This chapter concentrates on one of the most eutrophicated inner coastal waters of the German Southern Baltic, the Darß-Zingst Bodden in contrat to other more open coastal areas (e.g. Feuerpfeil et al. Estuar ...
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Chapter
Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons
Coastal lagoons provide important ecosystem services, but are simultaneously highly vulnerable. We aim at a better understanding of the mechanisms of ecosystem service production in these ecosystems. Three cas...
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Article
Open Access2D honeycomb transformation into dodecagonal quasicrystals driven by electrostatic forces
Dodecagonal oxide quasicrystals are well established as examples of long-range aperiodic order in two dimensions. However, despite investigations by scanning tunneling microscopy (STM), low-energy electron dif...
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Article
Open AccessSplenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance
Disease progression and relapse of chronic myeloid leukemia (CML) are caused by therapy resistant leukemia stem cells (LSCs), and cure relies on their eradication. The microenvironment in the bone marrow (BM) ...
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Article
Open AccessThe congruency of neuropsychological and F18-FDG brain PET/CT diagnostics of Alzheimer’s Disease (AD) in routine clinical practice: insights from a mixed neurological patient cohort
Diagnostics of Alzheimer’s Disease (AD) require a multimodal approach. Neuropsychologists examine the degree and etiology of dementia syndromes and results are combined with those of cerebrospinal fluid marker...
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Article
Open AccessPublisher Correction: ZnO nucleation into trititanate nanotubes by ALD equipment techniques, a new way to functionalize layered metal oxides
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Article
Open AccessZnO nucleation into trititanate nanotubes by ALD equipment techniques, a new way to functionalize layered metal oxides
In this contribution, we explore the potential of atomic layer deposition (ALD) techniques for develo** new semiconductor metal oxide composites. Specifically, we investigate the functionalization of multi-w...
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Article
Correction: 18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases
The author listing has been updated to indicate that Timo Grimmer and Kuangyu Shi are equally contributing authors.
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Article
Open Access18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases
18F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo...
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Article
18F-Fluoroethyl-tyrosine uptake is correlated with amino acid transport and neovascularization in treatment-naive glioblastomas
To investigate the in vivo correlation between 18F-fluoroethyl-tyrosine (18F-FET) uptake and amino acid transporter expression and vascularization in treatment-naive glioblastomas.
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Article
Functional Performance of Three Invasive Marenzelleria Species Under Contrasting Ecological Conditions Within the Baltic Sea
A 4-week laboratory experiment investigated the behaviour (survival and bioirrigation) and impact of the invasive polychaetes Marenzelleria viridis, M. neglecta and M. arctia on sediment-water solutes exchange, p...
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Chapter and Conference Paper
Learning Optimal Deep Projection of \(^{18}\) F-FDG PET Imaging for Early Differential Diagnosis of Parkinsonian Syndromes
Several diseases of parkinsonian syndromes present similar symptoms at early stage and no objective widely used diagnostic methods have been approved until now. Positron emission tomography (PET) with ...
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Article
Positron emission tomography and magnetic resonance spectroscopy in cerebral gliomas
Conventional MRI, the gold standard in structural brain imaging, alone has its limitations in pre-operative tumour grading, biopsy targeting, determination of accurate tumour margins prior to surgical resectio...
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Article
Intra-lesional spatial correlation of static and dynamic FET-PET parameters with MRI-based cerebral blood volume in patients with untreated glioma
18F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak s...
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Chapter and Conference Paper
Pattern Visualization and Recognition Using Tensor Factorization for Early Differential Diagnosis of Parkinsonism
Idiopathic Parkinsons disease (PD) and atypical parkinsonian syndromes may have similar symptoms at the early disease stage. Pattern recognition on metabolic imaging has been confirmed of distinct value in the...
