12 Result(s)

Article

Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats

1-Methylnicotinamide (MNA), a major endogenous metabolite of nicotinamide, possesses anti-thrombotic and anti-inflammatory activity, and reverses endothelial dysfunction. In the present work, we investigated w...

Cezary Watała, Piotr Kaźmierczak, Marcin Dobaczewski… in Pharmacological Reports (2009)

Article

Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis

Nicotinamide N-methyltrasferase (NMMT) catalyzes the conversion of nicotinamide (NA) to 1-methylnicotinamide (MNA). Recent studies have reported that exogenous MNA exerts anti-thrombotic and anti-inflammatory ...

Łukasz Mateuszuk, Tamara I. Khomich, Ewa Słomińska… in Pharmacological Reports (2009)

Article

Endurance training increases exercise-induced prostacyclin release in young, healthy men — relationship with VO_2max

In the present study, we evaluated the effect of 5 weeks of moderate-intensity endurance training on the basal and exercise-induced systemic release of prostacyclin (PGI²), as assessed by plasma 6-keto-PGF_1α conc...

Jerzy A. Zoladz, Joanna Majerczak, Krzysztof Duda… in Pharmacological Reports (2010)

Article

Endothelium — therapeutic target in stroke and neurodegenerative disorders

Ryszard T. Smoleński, Przemysław Kowiański, Monika Waśkow… in Pharmacological Reports (2011)

Article

Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6

Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide- N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in ...

Stefan Chłopicki, Marta Kurdziel, Magdalena Sternak… in Pharmacological Reports (2012)

Article

Different effects of nitrate and nitrite on hemostasis in rats

Karol Kramkowski, Agnieszka Leszczyńska, Kamil Przyborowski… in Pharmacological Reports (2013)

Article

Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq*44 mice

The timing and consequences of alternations in substrate utilization in heart failure (HF) and their relationship with structural changes remain unclear. This study aimed to analyze metabolic changes associate...

Elżbieta Czarnowska, Joanna B. Bierła, Marta Toczek… in Pharmacological Reports (2016)