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Open AccessFunctional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy metabolism. The aim of this study was to establish a Seahorse XFe96 ...
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Open AccessEarly microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin
Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxi...
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Article
Open AccessPlatelets in COVID-19 disease: friend, foe, or both?
Immuno-thrombosis of COVID-19 results in the activation of platelets and coagulopathy. Antiplatelet therapy has been widely used in COVID-19 patients to prevent thrombotic events. However, recent analysis of c...
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Open AccessComparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression
Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear.
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Open AccessAuthor Correction: MRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice
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Open AccessMRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice
Endothelial dysfunction is one of the hallmarks of vascular abnormalities in metabolic diseases and has been repeatedly demonstrated in coronary and peripheral circulation in mice fed high-fat diet (HFD), part...
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Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq*44 mice
The timing and consequences of alternations in substrate utilization in heart failure (HF) and their relationship with structural changes remain unclear. This study aimed to analyze metabolic changes associate...
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Antithrombotic effect of novel N-methynicotinamide-like structure (C2507)
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Antithrombotic effects of pyridinium compounds present in coffee beans
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Different effects of nitrate and nitrite on hemostasis in rats
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Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide- N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in ...
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Endothelium — therapeutic target in stroke and neurodegenerative disorders
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Editorial
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Endurance training increases exercise-induced prostacyclin release in young, healthy men — relationship with VO2max
In the present study, we evaluated the effect of 5 weeks of moderate-intensity endurance training on the basal and exercise-induced systemic release of prostacyclin (PGI2), as assessed by plasma 6-keto-PGF1α conc...
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Editorial
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Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats
1-Methylnicotinamide (MNA), a major endogenous metabolite of nicotinamide, possesses anti-thrombotic and anti-inflammatory activity, and reverses endothelial dysfunction. In the present work, we investigated w...
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Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis
Nicotinamide N-methyltrasferase (NMMT) catalyzes the conversion of nicotinamide (NA) to 1-methylnicotinamide (MNA). Recent studies have reported that exogenous MNA exerts anti-thrombotic and anti-inflammatory ...
