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Open AccessPlatelets in COVID-19 disease: friend, foe, or both?
Immuno-thrombosis of COVID-19 results in the activation of platelets and coagulopathy. Antiplatelet therapy has been widely used in COVID-19 patients to prevent thrombotic events. However, recent analysis of c...
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Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq*44 mice
The timing and consequences of alternations in substrate utilization in heart failure (HF) and their relationship with structural changes remain unclear. This study aimed to analyze metabolic changes associate...
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Antithrombotic effect of novel N-methynicotinamide-like structure (C2507)
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Antithrombotic effects of pyridinium compounds present in coffee beans
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Different effects of nitrate and nitrite on hemostasis in rats
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Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide- N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in ...
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Endothelium — therapeutic target in stroke and neurodegenerative disorders
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Editorial
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Endurance training increases exercise-induced prostacyclin release in young, healthy men — relationship with VO2max
In the present study, we evaluated the effect of 5 weeks of moderate-intensity endurance training on the basal and exercise-induced systemic release of prostacyclin (PGI2), as assessed by plasma 6-keto-PGF1α conc...
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Editorial
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Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats
1-Methylnicotinamide (MNA), a major endogenous metabolite of nicotinamide, possesses anti-thrombotic and anti-inflammatory activity, and reverses endothelial dysfunction. In the present work, we investigated w...
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Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis
Nicotinamide N-methyltrasferase (NMMT) catalyzes the conversion of nicotinamide (NA) to 1-methylnicotinamide (MNA). Recent studies have reported that exogenous MNA exerts anti-thrombotic and anti-inflammatory ...