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Article
Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model
Protein aggregation and the abnormal accumulation of aggregates are considered as common mechanisms of neurodegeneration such as Parkinson’s disease (PD). Ursolic acid (UA), a natural pentacyclic triterpenoid ...
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Article
Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson’s disease
Trehalose has been recently revealed as an attractive candidate to prevent and modify Parkinson’s disease (PD) progression by regulating autophagy; however, studies have only focused on the reduction of motor ...
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Article
Open AccessAmitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells
Amitriptyline is a tricyclic antidepressant commonly prescribed for major depressive disorders, as well as depressive symptoms associated with various neurological disorders. A possible correlation between the...
