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  1. No Access

    Article

    Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer

    Evolved resistance to tyrosine kinase inhibitor (TKI)-targeted therapies remains a major clinical challenge. In epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC), failure of EGFR T...

    Sana Raoof, Iain J. Mulford, Heidie Frisco-Cabanos, Varuna Nangia… in Oncogene (2019)

  2. No Access

    Article

    Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

    Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases 1–4 . Emerging data suggest that the strength and duration of IFN signaling can differentially imp...

    Huayang Liu, Javad Golji, Lauren K. Brodeur, Franklin S. Chung… in Nature Medicine (2019)

  3. No Access

    Article

    ATP-sensitive potassium channels mediate survival during infection in mammals and insects

    Specific homeostatic mechanisms confer stability in innate immune responses, preventing injury or death from infection. Here we identify, from a screen of N-ethyl-N-nitrosourea–mutagenized mice, a mutation causin...

    Ben Croker, Karine Crozat, Michael Berger, Yu **a, Sosathya Sovath… in Nature Genetics (2007)

  4. No Access

    Article

    The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

    Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stra...

    Koichi Tabeta, Kasper Hoebe, Edith M Janssen, **n Du, Philippe Georgel… in Nature Immunology (2006)

  5. No Access

    Article

    CD14 is required for MyD88-independent LPS signaling

    The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers. Macrophages from Heedless homozygotes signaled by...

    Zhengfan Jiang, Philippe Georgel, **n Du, Louis Shamel… in Nature Immunology (2005)

  6. No Access

    Article

    CD36 is a sensor of diacylglycerides

    Toll-like receptor 2 (TLR2) is required for the recognition of numerous molecular components of bacteria1,2,3,4,5,6,7,8, fungi9,10 and protozoa11. The breadth of the ligand repertoire seems unusual, even if one c...

    Kasper Hoebe, Philippe Georgel, Sophie Rutschmann, **n Du, Suzanne Mudd… in Nature (2005)