11 Result(s)

Article

Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance

Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through ac...

Sophie Vasseur, Fabienne Guillaumond in Oncogenesis (2022)

Article

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

Despite clinical advances in diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death, and is still associated with poor prognosis and dismal survival ra...

Angélina Acier, Magali Godard, Fanny Gassiot, Pascal Finetti… in Communications Biology (2021)

Article

Fountain of youth of pancreatic cancer cells: the extracellular matrix

Victoire Gouirand, Sophie Vasseur in Cell Death Discovery (2018)

Article

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork where nutrients and oxygen are sc...

Orianne Olivares, Jared R. Mayers, Victoire Gouirand… in Nature Communications (2017)

Article

Akt targeting as a strategy to boost chemotherapy efficacy in non-small cell lung cancer through metabolism suppression

Metabolic reprogramming is a hallmark of cancer development, mediated by genetic and epigenetic alterations that may be pharmacologically targeted. Among oncogenes, the kinase Akt is commonly overexpressed in ...

Marion Le Grand, Raphael Berges, Eddy Pasquier, Marie-Pierre Montero… in Scientific Reports (2017)

Article

Gene expression profiling of tumours derived from ras^V12/E1A-transformed mouse embryonic fibroblasts to identify genes required for tumour development

In cancer, cellular transformation is followed by tumour development. Knowledge on the mechanisms of transformation, involving activation of proto-oncogenes and inactivation of tumour-suppressor genes has cons...

Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Jean Charles Dagorn… in Molecular Cancer (2005)

Article

p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth

p8 is a stress-induced protein with multiple functions and biochemically related to the architectural factor HMG-I/Y. We analyzed the expression and function of p8 in pancreatic cancer-derived cells.

Cédric Malicet, Nathalie Lesavre, Sophie Vasseur, Juan L Iovanna in Molecular Cancer (2003)

Article

Mice with targeted disruption of p8gene show increased sensitivity to lipopolysaccharide and DNA microarray analysis of livers reveals an aberrant gene expression response

p8 is a DNA-binding protein induced in many tissues in response to LPS treatment. Hence, p8 could be a mediator of LPS-associated effects or, on the contrary, p8 expression may be part of the protective mechan...

Sophie Vasseur, Albrecht Hoffmeister, Andrés Garcia-Montero… in BMC Gastroenterology (2003)

Article

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras^V12 mutated protein and the E1A oncogene

Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important. We used a systematic approach, based on DNA microarray ...

Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Claude Labrie… in Molecular Cancer (2003)