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within Sooncheol Lee Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

    DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of bo...

    Colin W. Garvie, **aoyun Wu, Malvina Papanastasiou, Sooncheol Lee… in Nature Communications (2021)

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