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Open AccessFactors associated with chronic obstructive pulmonary disease exacerbation, based on big data analysis
Preventing exacerbation in chronic obstructive pulmonary disease (COPD) patients is crucial, but requires identification of the exacerbating factors. To date, no integrated analysis of patient-derived and exte...
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Article
Open AccessCooperation in publicly funded reference material production
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Article
Quantification of recombinant human erythropoietin by amino acid analysis using isotope dilution liquid chromatography–tandem mass spectrometry
Herein, we describe an accurate method for protein quantification based on conventional acid hydrolysis and an isotope dilution-ultra performance liquid chromatography–tandem mass spectrometry method. The anal...
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Article
Erratum to X-ray structure of prephenate dehydratase from Streptococcus mutans
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Article
X-ray structure of prephenate dehydratase from Streptococcus mutans
Prephenate dehydratase is a key enzyme of the biosynthesis of L-phenylalanine in the organisms that utilize shikimate pathway. Since this enzymatic pathway does not exist in mammals, prephenate dehydratase can...
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Article
Amino acid analysis of dried blood spots for diagnosis of phenylketonuria using capillary electrophoresis-mass spectrometry equipped with a sheathless electrospray ionization interface
We describe a capillary electrophoresis-mass spectrometry (CE-MS) method for newborn screening of a representative amino acid metabolic disease, namely, phenylketonuria (PKU). Underivatized phenylalanine and t...
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Article
Rapid and accurate determination of deoxyribonucleoside monophosphates from DNA using micellar electrokinetic chromatography with a cationic surfactant additive
A micellar electrokinetic chromatography (MEKC) method for rapid and accurate determination of 2′-deoxyribonucleoside 5′-monophosphates (dNMPs), four structural elements of DNA, is described. MEKC separation a...
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Article
Syntheses and Cation Complexation Studies of New Cavitand Derivatives
A series of new cavitands containing four esters, nitriles, 2-pyridyl, or 3-pyridyl groups were synthesized fromtetrahydroxycavitand. Their binding properties towards various metal ions are investigated.
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Article
New Fluorescent Chemosensors for Cationic Guests: 1,8-Bis(azacrown)anthracenes
New macrocyclic ditopic anthracenyl receptors display largechelation-enhanced fluorescence (CHEF) effects upon the addition of linear dications+NH3(CH2)nNH3 +. The amplitude of the effect, which is dependent on t...
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Article
In vitro andin vivo activities of SM-101, a mixture of metampicillin and sulbactam
SM-101 is a mixture of metampicillin and sulbactam(2∶1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activitie...