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Article
Open AccessMimicking chronic alcohol effects through a controlled and sustained ethanol release device
Alcohol consumption, a pervasive societal issue, poses considerable health risks and socioeconomic consequences. Alcohol-induced hepatic disorders, such as fatty liver disease, alcoholic hepatitis, chronic hep...
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Article
Open AccessSubstrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation
The aminopeptidase activity (AP) of the leukotriene A4 hydrolase (LTA4H) enzyme has emerged as a therapeutic target to modulate host immunity. Initial reports focused on the benefits of augmenting the LTA4H AP ac...
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Article
Open AccessChemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer cohort of 146 patients including 110 pa...
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Article
Open AccessCanine non-B, non-T NK lymphocytes have a potential antibody-dependent cellular cytotoxicity function against antibody-coated tumor cells
The antibody-dependent cellular cytotoxicity (ADCC) is a cell-mediated immune defense mechanism in which effector immune cells actively lyse antibody-coated target cells. The ADCC of tumor cells is employed in...
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Article
Open AccessDoes guideline non-adherence result in worse clinical outcomes for hormone receptor-positive and HER2-negative metastatic breast cancer in premenopausal women?: result of an institution database from South Korea
In this study, we observe the patterns initial palliative treatment for premenopausal patients with HR-positive/HER2-negative MBC and determine if nonadherence to clinical guidelines are associated with worse ...
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Chapter
Material-Independent Surface Modification Inspired by Principle of Mussel Adhesion
Mussels’ unique ability to adhere virtually any surfaces of materials underwater has drawn significant attention to scientists and engineers. This chapter will introduce a new concept of surface chemistry call...
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Article
A prospective randomized controlled trial of hydrating nail solution for prevention or treatment of onycholysis in breast cancer patients who received neoadjuvant/adjuvant docetaxel chemotherapy
Onycholysis and other nail toxicities occur in approximately 20–30% of breast cancer (BC) patients receiving docetaxel chemotherapy. Onycholysis is often associated with painful paronychia, decreasing patients...
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Article
Open AccessStatins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency
We investigated the molecular mechanisms underlying statin-induced growth suppression of triple-negative breast cancer (TNBC) that overexpress the transcription factor ets proto-oncogene 1(ets-1) and downregul...
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Article
Open AccessStatins and the risk of gastric cancer in diabetes patients
Several studies have suggested a cancer risk reduction in statin users although the evidence remains weak for stomach cancer. The purpose of this study was to use an exact-matching case–control design to exami...
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Article
Self-crosslinked polyethylenimine nanogels for enhanced intracellular delivery of siRNA
Branched polyethylenimine (bPEI) (M w =25 k) conjugated with catechol groups (PEI-C) was crosslinked to produce PEI-catechol nanogels (PCNs), which were ...
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Article
The clinical significance of ascitic fluid CEA in advanced gastric cancer with ascites
This study was carried out to evaluate the clinical significance of ascitic fluid carcinoembryonic antigen (CEA) in advanced gastric cancer patients with ascites.
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Article
Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing
Small interfering RNA (siRNA) with 19–21 base pairs has been recently recognized as a new therapeutic agent for effectively silencing a specific gene on a post-transcription level. For siRNA therapeutics, safe...
