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Article
Open AccessThe effect of co** strategies on health–related quality of life in acromegaly patients
Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive co** styles are associated with poor HRQoL in a number of diseases and pat...
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Article
Open AccessExploring potential influencing factors of inadherence to specialist aftercare and long-term medication in patients with acromegaly
To improve the understanding of adherence as one major factor of disease control in acromegaly patients, we systematically assessed patients’ motivations to adhere to advised follow-up schedules and recommende...
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Article
Open AccessMedizinische Versorgung von Menschen mit Foltererfahrung: Trainings zu Folter(folgen) sind wichtig; strukturelle Herausforderungen sind ungelöst
Folter ist weltweit verbreitet, u. a. in Ländern, aus denen Menschen fliehen, um in Deutschland Asyl zu beantragen. Menschen mit Foltererfahrung stellen eine vulnerable Gruppe dar und benötigen eine adäquate V...
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Article
Open AccessSchwere sexualisierte Gewalt – Aufklärung eines Falls durch Kombination aus DNA- und mRNA-Analyse
Mithilfe der Analyse von mRNA-Expressionsmustern durch Einsatz der PCR-Amplifikation von zellspezifischen cDNA-Transkripten und Nachweis der Amplifikate mittels Kapillarelektrophorese (CE) lässt sich die Frage...
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Article
Open AccessMotivation for and adherence to growth hormone replacement therapy in adults with hypopituitarism: the patients‘ perspective
While reasons for non-adherence in children requiring growth hormone (GH) replacement (GH-Rx) are well researched, few studies have investigated adherence in adult GH deficient patients. Against the background...
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Article
Oro-dental pathologies in acromegaly
Oro-dental pathologies (ODP) such as enlargement of the tongue, mandibular prognathism, and spaced teeth are characteristic features of acromegaly. Their frequency of occurrence during the course of the diseas...
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Article
Presence of headache and headache types in patients with tumors of the sellar region—can surgery solve the problem? Results of a prospective single center study
Headache is a common presenting feature of patients with pituitary adenomas and other tumors of the sellar region. However, at present, it still is unclear whether the headache is actually caused by the tumor....
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Article
Co** strategies have a strong impact on quality of life, depression, and embitterment in patients with Cushing’s disease
Quality of life (QoL) and psychosocial well-being are substantially impaired in patients with Cushing’s disease (CD), not only at the acute illness stage but also after therapy; however, the reason for these i...
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Article
Diagnosis and management of acromegaly: the patient’s perspective
Early diagnosis is a success factor for the prevention of long-term comorbidity and premature death in patients with acromegaly, but large-scale data on the diagnostic process and disease management are scarce...
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Article
Open AccessEZH2 is highly expressed in pituitary adenomas and associated with proliferation
Enhancer of zeste homolog 2 (EZH2) is a core epigenetic regulator, playing a crucial role in cell cycle regulation. The protein is known to be associated with proliferation and worse outcome in several tumor e...
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Article
Diagnostic delay is associated with psychosocial impairment in acromegaly
The aim of this study was to systematically assess health care utilisation, diagnostic delay and psychosocial impairment in patients with acromegaly in rural versus urban health care environments. 41 patients ...
