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Article
Open AccessARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
Medulloblastoma, the most common malignant pediatric brain tumor, often harbors MYC amplifications. Compared to high-grade gliomas, MYC-amplified medulloblastomas often show increased photoreceptor activity and a...
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Article
No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients
Neurofibromatosis type 1 (NF1) is a common monogenic disorder whereby affected individuals are predisposed to develo** CNS tumors, including optic pathway gliomas (OPGs, occurring in ~15 to 20 % of cases). S...
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Article
Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants
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Article
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
Stefan Pfister and the ICGC PedBrain Tumor Project report whole-genome sequencing of 96 pilocytic astrocytomas. They identify recurrent activating mutations in FGFR1 and PTPN11 and novel NTRK2 fusion genes.
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Article
Open AccessDissecting the genomic complexity underlying medulloblastoma
Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal...
