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Article
Open AccessExtraction of high quality and high yield RNA from frozen EDTA blood
Peripheral blood RNA profiling, which can reveal systemic changes in gene expression and immune responses to disease onset and progression, is a powerful tool for diagnosis and biomarker discovery. This techni...
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Article
Fimbristylis ovata and Artemisia vulgaris extracts inhibited AGE-mediated RAGE expression, ROS generation, and inflammation in THP-1 cells
Advanced glycation end products (AGEs) can induce inflammatory signaling pathways through the receptor for AGEs (RAGE). Targeting RAGE could be a therapeutic strategy for treating chronic inflammation mediated...
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Article
Open AccessMetabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation
Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss ...
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Article
Open AccessPublisher Correction: Non-invasive assessment of exfoliated kidney cells extracted from urine using multispectral autofluorescence features
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Article
Open AccessLysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse
Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction ...
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Article
Open AccessNon-invasive assessment of exfoliated kidney cells extracted from urine using multispectral autofluorescence features
Optimally preserved urinary exfoliated renal proximal tubule cells were assessed by multispectral imaging of cell autofluorescence. We demonstrated different multispectral autofluorescence signals in such cell...
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Article
Open AccessOffspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice
Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ...
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The Developmental Mechanisms of Obesity by Maternal Obesity
is a major global concern due to its alarming and associated risks for multiple diseases. The rate of has nearly tripled in the last four decades and amounting evidence is implying a critical role of de...
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Article
Open AccessL-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury
There is a need for pharmaceutical agents that can reduce neuronal loss and improve functional deficits following traumatic brain injury (TBI). Previous research suggests that oxidative stress and mitochondria...
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Article
Open AccessLysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy
Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key...
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Article
Open AccessMitoQ supplementation prevent long-term impact of maternal smoking on renal development, oxidative stress and mitochondrial density in male mice offspring
To investigate the effect of maternal MitoQ treatment on renal disorders caused by maternal cigarette smoke exposure (SE). We have demonstrated that maternal SE during pregnancy increases the risk of developin...
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Article
Open AccessSIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
Rodent models of maternal obesity have been associated with kidney damage and dysfunction in offspring. However, the underlying mechanisms are yet to be elucidated. In this study, female rats were fed a high-f...
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Article
Open AccessMaternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring
Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal ...
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Article
Open AccessImpact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring
Maternal cigarette smoke exposure (SE) during gestation can cause lifelong adverse effects in the offspring’s brain. Several factors may contribute including inflammation, oxidative stress and hypoxia, whose c...
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Article
Open AccessQuantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features
Automated and unbiased methods of non-invasive cell monitoring able to deal with complex biological heterogeneity are fundamentally important for biology and medicine. Label-free cell imaging provides informat...
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Article
Open AccessEffect of GLP-1 Receptor Activation on Offspring Kidney Health in a Rat Model of Maternal Obesity
Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D). Exendin-4 (Exd-4) activates the glucagon like peptide-1 (GLP-1) receptor thereby decreasi...
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Article
Open AccessFXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity
Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is recognized that maternal obesity predisposes offsp...
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Article
Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents
Maternal obesity leads to increased adiposity, hyperlipidaemia and glucose intolerance in offspring. The analogue of glucagon-like peptide-1, exendin-4 (Ex-4), has been shown to induce weight loss in both adol...
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Article
Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts
Two invasive breast cancer cell lines (MDA-MB-231 and BT-549) were found to be more adherent and have greater migratory capacity on bone marrow fibroblasts than three non-invasive cell lines (MCF-7, T47D and B...
