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Article
Open AccessControl of CXCR2 activity through its ubiquitination on K327 residue
The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reporte...
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Article
Open AccessNegative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
NF-κB is a master gene regulator involved in plethora of biological processes, including lymphocyte activation and proliferation. Reversible ubiquitinylation of key adaptors is required to convey the optimal a...