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Article
Open AccessNegative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
NF-κB is a master gene regulator involved in plethora of biological processes, including lymphocyte activation and proliferation. Reversible ubiquitinylation of key adaptors is required to convey the optimal a...
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Article
Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma
The protein Puma (p53-upregulated modulator of apoptosis) belongs to the BH3-only group of the Bcl-2 family and is a major regulator of apoptosis. Although the transcriptional regulation of Puma is clearly est...