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Article
Open AccessNovel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions
TMC1, which encodes transmembrane channel-like protein 1, forms the mechanoelectrical transduction (MET) channel in auditory hair cells, necessary for auditory function. TMC1 variants are known to cause autosomal...
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Article
Open AccessNFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells
Cytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines play key roles in immunodeficiencies, autoimmune diseases, allergies, a...
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Article
Open AccessWFS1 autosomal dominant variants linked with hearing loss: update on structural analysis and cochlear implant outcome
Wolfram syndrome type 1 gene (WFS1), which encodes a transmembrane structural protein (wolframin), is essential for several biological processes, including proper inner ear function. Unlike the recessively inheri...
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Article
Open AccessPowerful use of automated prioritization of candidate variants in genetic hearing loss with extreme etiologic heterogeneity
Variant prioritization of exome sequencing (ES) data for molecular diagnosis of sensorineural hearing loss (SNHL) with extreme etiologic heterogeneity poses a significant challenge. This study used an automate...
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Article
Open AccessEffects of intranasal instillation of nanoparticulate matter in the olfactory bulb
Nanoparticulate matter activates the aryl hydrocarbon receptor (AhR) pathway in the respiratory system in a process involving the AhR nuclear translocator (ARNT) and cytochrome P450 family 1, member A1 (CYP1A1...
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Article
Changes in the Gene Expression Profiles of the Inferior Colliculus Following Unilateral Cochlear Ablation in Adult Rats
This study aimed to explore gene expression changes in the inferior colliculus (IC) after single-sided deafness (SSD). Forty 8-week-old female Sprague–Dawley rats were used. Twenty rats underwent right-side co...
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Article
Open AccessOverexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss
The receptor for advanced glycation end-products (RAGE) is involved in neuroinflammation. This study investigated the changes in RAGE expression following noise-induced hearing loss.
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Article
Open AccessEffect of acute noise trauma on the gene expression profile of the hippocampus
This study aimed to investigate the changes in the expression of hippocampal genes upon acute noise exposure.
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Article
Open AccessOral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats
Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety r...
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Article
Open AccessNoise exposure alters MMP9 and brevican expression in the rat primary auditory cortex
This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–D...
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Article
Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases
To investigate the important diagnostic indicators for blood stasis syndrome (BSS) in patients of childbearing age with gynaecological diseases.
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Article
The effectiveness of anti-biofilm and anti-virulence properties of dihydrocelastrol and dihydrocelastryl diacetate in fighting against methicillin-resistant Staphylococcus aureus
Human pathogens have readily been converted into multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), because of the long-term use of conventional antibiotics. In addition, t...
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Article
Activity of novel inhibitors of Staphylococcus aureus biofilms
Staphylococcus aureus is one of the most important pathogens causing chronic biofilm infections. These are becoming more difficult to treat owing to drug resistance, particularly because
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Article
Effect of Paeotang on tumor necrosis factor α-induced vascular inflammation in human umbilical vein endothelial cells
To investigate whether Paeotang (10–50 μg/mL) suppresses tumor necrosis factor α (TNF-α)-induced vascular inflammatory processes in human umbilical vein endothelial cells (HUVEC).
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Article
Forensic analysis using microbial community between skin bacteria and fabrics
Microorganisms flourish on and in the human body and skin surfaces are the largest. The skin surface microbiota can be transferred to an object upon touch. This has forensic implications. This study explored t...
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Article
Open AccessConcurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC
Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1, encoding a constitutive active bone morphogenetic protein type I receptor (also called ALK2) to induce heterotopic oss...
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Article
Phlebosclerotic colitis: case report and literature review focused on the radiologic findings in relation to the intake period of toxic material
Phlebosclerotic colitis (PC) is a rare disease entity of intestinal ischemia characterized by calcification at the right hemicolon and is predominant in Asian populations. We present a 57-year-old Korean patie...
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Article
Open AccessOryeongsan suppressed high glucose-induced mesangial fibrosis
The pathological change of kidney in diabetic nephropathy is represented hypertrophy, inflammation, and renal fibrosis. Oryeongsan, traditional oriental herbal formula, is widely used for the treatment of neph...
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Article
Open AccessGal-geun-dang-gwi-tang improves diabetic vascular complication in apolipoprotein E KO mice fed a western diet
Gal-geun-dang-gwi-tang (GGDGT), an herbal medicine, is used to treat hypertension, stroke, and other inflammatory disorders in the clinical setting. Recently, GGDGT was recognized by the Korea Institute of Ori...
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Article
Open AccessGold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity
We report a gold nanoparticle (AuNP)-based fluorescence quenching system via metal coordination for the simple assay of protease activity. Carboxy AuNPs (5 nm in core diameter) functioned as both quenchers and...
