Skip to main content

8 Result(s)

within Snjezana Lelas Remove this filter

and

  1. No Access

    Article

    Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors

    Conflict procedures are used to study mechanisms underlying the anxiolytic effects of benzodiazepines (BZs). We established a conflict procedure with rhesus monkeys in order to examine the role of GABAA receptors...

    James K. Rowlett, Snjezana Lelas, Walter Tornatzky… in Psychopharmacology (2006)

  2. No Access

    Article

    Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

    Benzodiazepines continue to be widely used for the treatment of anxiety, but it is well known that benzodiazepines have undesirable side effects, including sedation, ataxia, cognitive deficits and the risk of ...

    John B. Hogan, Donald B. Hodges Jr, Snjezana Lelas, Paul J. Gilligan… in Psychopharmacology (2005)

  3. No Access

    Article

    The anxiolytic CRF1 antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

    Compounds with a mechanism of action different from benzodiazepines may retain the anxiolytic effects of benzodiazepines with fewer side effects. CRF1 antagonists have anxiolytic-like effects but may have differe...

    Snjezana Lelas, Kim L. Zeller, Kathryn A. Ward, John F. McElroy in Psychopharmacology (2003)

  4. No Access

    Article

    Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABAA/α1 receptors

    Abstract

    James K. Rowlett, Roger D. Spealman, Snjezana Lelas, James M. Cook… in Psychopharmacology (2003)

  5. No Access

    Article

    The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

    Abstract

    John F. McElroy, Kathryn A. Ward, Kim L. Zeller, Keith W. Jones… in Psychopharmacology (2002)

  6. No Access

    Article

    Role of GABAA/benzodiazepine receptors containing α1 and α5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys

    Rationale: Conventional benzodiazepines (BZs), clinically used for treatment of anxiety and insomnia, bind to GABAA receptors containing α1, α2, α3, or α5 subunits. The role of these different GABAA receptor subt...

    Snjezana Lelas, James K. Rowlett, Roger D. Spealman, James M. Cook… in Psychopharmacology (2002)

  7. No Access

    Article

    Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam

    Rationale: The discriminative stimulus (DS) effects of chlordiazepoxide (CDP) differ from those of other typical benzodiazepine (BZ) agonists in that CDP does not always occasion full substitution for a BZ agonis...

    Snjezana Lelas, James K. Rowlett, Roger D. Spealman in Psychopharmacology (2001)

  8. No Access

    Article

    Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs

    Rationale: Triazolam is a high-efficacy benzodiazepine (BZ) agonist, which might be hypothesized to engender highly pharmacologically specific discriminative stimulus (DS) effects and distinguish among BZ agonis...

    Snjezana Lelas, James K. Rowlett, Roger D. Spealman in Psychopharmacology (2001)