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  1. No Access

    Article

    Assessing and engineering the IscB–ωRNA system for programmed genome editing

    OMEGA RNA (ωRNA)-guided endonuclease IscB, the evolutionary ancestor of Cas9, is an attractive system for in vivo genome editing because of its compact size and mechanistic resemblance to Cas9. However, wild-t...

    Hao Yan, **aoqing Tan, Siyuan Zou, Yihong Sun, Ailong Ke… in Nature Chemical Biology (2024)

  2. Article

    Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity

    Tong Wu, Chang Liu, Siyuan Zou, Ruitu Lyu, Bowei Yang, Hao Yan… in Nature Chemical Biology (2024)

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  3. No Access

    Article

    An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity

    Compact CRISPR-Cas systems offer versatile treatment options for genetic disorders, but their application is often limited by modest gene-editing activity. Here we present enAsCas12f, an engineered RNA-guided ...

    Tong Wu, Chang Liu, Siyuan Zou, Ruitu Lyu, Bowei Yang, Hao Yan… in Nature Chemical Biology (2023)