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Article

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for deve...

Jesse J Smith, Renée Deehan Kenney, David J Gagne, Brian P Frushour… in BMC Systems Biology (2009)