-
Article
Open AccessHuman thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq
Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negat...
-
Article
Open AccessCorrelation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identi...
-
Article
Open AccessTranscriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells
The thymus is a highly specialized organ of the immune system where T cell precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date have investigated how the human trans...
