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Article
Open AccessA multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity
Within the past decade, incremental integration of molecular characteristics into the classification of central nervous system neoplasms increasingly facilitated precise diagnosis and advanced stratification, ...
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Article
Open AccessPituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Pituitary neuroendocrine tumors (PitNETs) are classified according to cell lineage, which requires immunohistochemistry for adenohypophyseal hormones and the transcription factors (TFs) PIT1, SF1, and TPIT. Ac...
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Article
Open AccessComplement and MHC patterns can provide the diagnostic framework for inflammatory neuromuscular diseases
Histopathological analysis stands as the gold standard for the identification and differentiation of inflammatory neuromuscular diseases. These disorders continue to constitute a diagnostic challenge due to th...
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Chapter
Popular Entrepreneurship: A Marketing and Social Evaluation View on Evaluation Regimes
Entrepreneurial archetypes, such as the hero or lone wolf, are being replaced by metaphorical images like gazelles or unicorns, accompanied by a spread of evaluation regimes that highlight selected types of fi...
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Article
Open AccessHistopathologically confirmed radiation-induced damage of the brain – an in-depth analysis of radiation parameters and spatio-temporal occurrence
Radiation-induced damage (RID) after radiotherapy (RT) of primary brain tumors and metastases can be challenging to clinico-radiographically distinguish from tumor progression. RID includes pseudoprogression a...
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Article
Open AccessMetastases to the pituitary gland: insights from the German pituitary tumor registry
Metastatic involvement of the pituitary gland is a rare but clinically significant phenomenon, that often poses diagnostic and therapeutic challenges. The aim of this study was to provide a comprehensive analy...
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Article
Open AccessDiffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor characterized by a specific DNA methylation profile. It was recently introduced in the 5th Wo...
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Article
Open AccessClass I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells
We and others have demonstrated that MYC-amplified medulloblastoma (MB) cells are susceptible to class I histone deacetylase inhibitor (HDACi) treatment. However, single drug treatment with HDACi has shown limite...
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Article
Open AccessDNA methylation-based classification of sinonasal tumors
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SN...
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Article
Open AccessGenetic and epigenetic characterization of posterior pituitary tumors
Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be challenging to distinguish and have been proposed to re...
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Article
Open AccessPATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and ...
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Article
Open AccessGenome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas
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Chapter and Conference Paper
QVIREA Eine Qualifizierungsinitiative im datengestützten, überbetrieblichen Qualitätsmanagement in Lebensmittelketten
Trotz der heterogenen Wahrnehmung und Evaluierung des aktuellen Digitalisierungstrends in der Landwirtschaft gewinnen digitale Lösungen aufgrund ihrer Möglichkeiten auch im Qualifizierungsbereich der Branche a...
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Article
Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1
Rosette-forming glioneuronal tumor (RGNT) is a rare brain neoplasm that primarily affects young adults. Although alterations affecting the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase ...
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Article
Correction to: DNA methylation-based reclassification of olfactory neuroblastoma
In the original publication, the second name of the twentieth author was incorrect. It should read as ‘Miguel Sáinz-Jaspeado’. The original publication of the article has been updated to reflect the change. Th...
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Article
DNA methylation-based reclassification of olfactory neuroblastoma
Olfactory neuroblastoma/esthesioneuroblastoma (ONB) is an uncommon neuroectodermal neoplasm thought to arise from the olfactory epithelium. Little is known about its molecular pathogenesis. For this study, a r...
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Article
Open AccessPractical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based c...
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Article
Gastric mucosal lacerations in drowning: resuscitation artifact or sign of death by drowning (“Sehrt’s sign”)?
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Article
Open AccessA global microRNA screen identifies regulators of the ErbB receptor signaling network
The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission reli...
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Article
Three rounds as “tandem bullets”: unusual findings in a case of a suicidal gunshot to the head
We report an unusual case of suicide in which three 7.65 caliber projectiles were found in the single gunshot wound to the head of a 53-year-old man. Based on data collected at the death scene, CT scan, autops...
