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  1. Article

    Open Access

    PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

    Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we ai...

    Kai Zimmer, Florian Kocher, Gerold Untergasser, Brigitte Kircher… in npj Precision Oncology (2023)

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  2. No Access

    Protocol

    Screening for MAPK Modulators Using an In-Cell Western Assay

    Several essential cellular functions are critically influenced by the Ras-Raf-MEK-ERK cascade, and pathological problems have been implicated with loss as well as gain of its activity. Therefore, there is a gr...

    Simon Schnaiter, Beatrix Fürst, Johannes Neu, Frigyes Wáczek, László Őrfi… in Ras Signaling (2014)