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Open AccessEffectiveness of a nurse-led management intervention on systolic blood pressure among type 2 diabetes patients in Uganda: a cluster randomized trial
Hypertension (HT) is an orchestrator of atherosclerotic cardiovascular disease (ASCVD) in people living with type 2 diabetes (T2D). Control of systolic blood pressure (SBP) and HT as a whole is suboptimal in d...
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Hypertension care cascades and reducing inequities in cardiovascular disease in low- and middle-income countries
Improving hypertension control in low- and middle-income countries has uncertain implications across socioeconomic groups. In this study, we simulated improvements in the hypertension care cascade and evaluate...
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Article
Type 1 diabetes patient experiences and management practices during the COVID-19 pandemic in rural Uganda
The COVID-19 pandemic has impacted various aspects of the lives of persons with chronic diseases, including type 1 diabetes (T1D). However, the diabetes care experiences and practices adopted by persons living...
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Open AccessSubgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population
Adult-onset diabetes mellitus (here: aDM) is not a uniform disease entity. In European populations, five diabetes subgroups have been identified by cluster analysis using simple clinical variables; these may e...
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Open AccessGenome-wide DNA methylation analysis on C-reactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseases
Molecular mechanisms at the intersection of inflammation and cardiovascular diseases (CVD) among Africans are still unknown. We performed an epigenome-wide association study to identify loci associated with se...
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Open AccessFood intake and cardiometabolic risk factors in rural Uganda
Along with a nutritional transition in Sub-Saharan Africa, the prevalence of non-communicable diseases is increasing rapidly. We assess the association between food intake and cardiometabolic risk factors in a...
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Article
Open AccessEffect of a nurse-led lifestyle choice and coaching intervention on systolic blood pressure among type 2 diabetic patients with a high atherosclerotic cardiovascular risk: study protocol for a cluster-randomized trial
More than 50% of patients with type 2 diabetes have hypertension in Uganda. Diabetic patients with elevated systolic blood pressure experience higher all-cause mortality and cardiovascular events compared with...
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“Fat People Are More Respected”: Socio-Cultural Construction of Obesity and Overweight Risk & Prevention in Ugandan Communities
Non-communicable diseases (NCDs) are now the leading cause of death in most regions of the world and are on the increase in develo** countries. The intermediate risk factors shared by these diseases are rais...
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Open AccessAfrican Cuisine-Centered Insulin Therapy: Expert Opinion on the Management of Hyperglycaemia in Adult Patients with Type 2 Diabetes Mellitus
The prevalence of diabetes in sub-Saharan Africa (SSA) is growing rapidly, and a steadily increasing number of adults are estimated to be living with type 2 diabetes mellitus (T2DM). Insulin therapy is the tre...
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Open AccessDifferential associations between psychosocial stress and obesity among Ghanaians in Europe and in Ghana: findings from the RODAM study
Psychosocial stress is associated with obesity in some populations, but it is unclear whether the association is related to migration. This study explored associations between psychosocial stress and obesity a...
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Open AccessGlucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group
The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in...
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Open AccessIs social support associated with hypertension control among Ghanaian migrants in Europe and non-migrants in Ghana? The RODAM study
Hypertension (HTN) control is crucial in preventing HTN-related complications such as stroke and coronary heart disease. Yet, HTN control remains suboptimal particularly among sub-Saharan African (SSA) populat...
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Article
Diabetes management and treatment approaches outside of North America and West Europe in 2006 and 2015
The impact of introducing new classes of glucose-lowering medication (GLM) on diabetes management remains unclear, especially outside North America and Western Europe. Therefore, we aimed to analyse trends in ...
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Open AccessEarly-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study
Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for i...
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Article
Open AccessEuthymia in Diabetes: Clinical Evidence and Practice-Based Opinion from an International Expert Group
To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.
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Open AccessEADSG Guidelines: Insulin Storage and Optimisation of Injection Technique in Diabetes Management
To date, insulin therapy remains the cornerstone of diabetes management; but the art of injecting insulin is still poorly understood in many health facilities. To address this gap, the Forum for Injection Tech...
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Article
Autoantibodies and HLA class II DR-DQ genotypes in Ugandan children and adolescents with type 1 diabetes mellitus
The aims were to determine the prevalence of autoantibodies in type 1 diabetes mellitus (T1DM) and further to investigate the human leukocyte antigen (HLA) class II DR-DQ genotypes associated with T1DM in Ugan...
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Open AccessExpert Opinion: Patient Selection for Premixed Insulin Formulations in Diabetes Care
Premixed insulins are an important tool for glycemic control in persons with diabetes. Equally important in diabetes care is the selection of the most appropriate insulin regimen for a particular individual at...
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Open AccessIdeal cardiovascular health among Ghanaian populations in three European countries and rural and urban Ghana: the RODAM study
Cardiovascular health (CVH) is a construct defined by the American Heart Association (AHA) as part of its 2020 Impact Goal definition. CVH has, until now, not been evaluated in Sub-Saharan African populations....
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Open AccessAn epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among A...
