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  1. Article

    Open Access

    Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS

    Polyploidy has been recognized for many years as an important hallmark of cancer cells. Polyploid cells can arise through cell fusion, endoreplication and abortive cell cycle. The inner nuclear membrane protein L...

    Shirley Oren Ben-Shoshan, Amos J Simon, Jasmine Jacob-Hirsch… in Molecular Cytogenetics (2014)

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    Article

    Enhanced expression of the nuclear envelope LAP2 transcriptional repressors in normal and malignant activated lymphocytes

    Extensive research in recent years has broadened the functions of nuclear envelope proteins beyond simply stabilizing the nucleus architecture. Particularly, integral nuclear membrane proteins, such as the alt...

    Raz Somech, Einav Nili Gal-Yam, Sigal Shaklai, Orit Geller… in Annals of Hematology (2007)

  3. Article

    Nuclear Envelopathies—Raising the Nuclear Veil

    The nuclear envelope separates the chromosomes from cytoplasm in eukaryotic cells and consists of three main domains: inner and outer nuclear membranes and nuclear pore complexes. The inner nuclear membrane ma...

    Raz Somech, Sigal Shaklai, Ninette Amariglio, Gideon Rechavi… in Pediatric Research (2005)

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