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Article
Open AccessClinical and cost-effectiveness of paramedic administered fascia iliaca compartment block for emergency hip fracture (RAPID 2)—protocol for an individually randomised parallel-group trial
Approximately 75,000 people fracture a hip each year in the UK. This painful injury can be devastating—with a high associated mortality rate—and survivors likely to be more dependent and less mobile. Pain reli...
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Article
Open AccessAutomated next-generation profiling of genomic alterations in human cancers
The lack of validated, distributed comprehensive genomic profiling assays for patients with cancer inhibits access to precision oncology treatment. To address this, we describe elio tissue complete, which has ...
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Reference Work Entry In depth
Ucko, Peter (Cultural Heritage Management)
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Article
Open AccessRapid Analgesia for Prehospital hip Disruption (RAPID): findings from a randomised feasibility study
In managing hip fracture, effective pain relief before admission to hospital is difficult without risking side effects. Although emergency departments routinely use fascia iliaca compartment block (FICB), ther...
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Article
Open AccessHigh grade serous ovarian carcinomas originate in the fallopian tube
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evid...
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Article
Initial biochar effects on plant productivity derive from N fertilization
Biochar application to soil is widely claimed to increase plant productivity. However, the underlying mechanisms are still not conclusively described. Here, we aim to elucidate these mechanisms using stable is...
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Article
Open Access“Hitting the spot”: Develo** individuals with lived-experience of health and social care as facilitators to deliver a course to enhance public involvement in research – a Welsh perspective
Public involvement in research has become an important and integral part of the research process in health and social care, from the early stages of research prioritisation and development to the later stages ...
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Article
Open AccessRapid analgesia for prehospital hip disruption (RAPID): protocol for feasibility study of randomised controlled trial
Adequate pain relief at the point of injury and during transport to hospital is a major challenge in all acute traumas, especially for those with hip fractures, whose injuries are difficult to immobilise and w...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Article
The genomic landscape of response to EGFR blockade in colorectal cancer
The effect of somatic genetic changes in colorectal cancer on sensitivity to anti-EGFR antibody therapy is analysed.
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Article
Open AccessTargeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia (AAH). Evidence suggests that AAH repres...
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Article
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients
Pancreatic adenocarcinoma has the worst mortality of any solid cancer. In this study, to evaluate the clinical implications of genomic alterations in this tumour type, we perform whole-exome analyses of 24 tum...
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Article
Familial and sporadic pancreatic cancer share the same molecular pathogenesis
Pancreatic ductal adenocarcinoma (PDAC) is nearly uniformly lethal, with a median overall survival in 2014 of only 6 months. The genetic progression of sporadic PDAC (SPC) is well established, with common soma...
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Article
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
Chetan Bettegowda, Bert Vogelstein and colleagues identify somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors from individuals with and without neurofibromatosis. SUZ12 encodes a chromatin-mod...
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Article
Open AccessGenomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes
Malignant mixed Müllerian tumours, also known as carcinosarcomas, are rare tumours of gynaecological origin. Here we perform whole-exome analyses of 22 tumours using massively parallel sequencing to determine ...
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Article
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
Hai Yan, Zachary Reitman and colleagues report exome sequencing of resected tumor tissue from brainstem gliomas and thalamic gliomas and identify mutations in PPM1D in brainstem gliomas.
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Reference Work Entry In depth
Ucko, Peter (Cultural Heritage Management)
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Article
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
Victor Velculescu, Michael Hogarty and colleagues report whole-genome and exome sequences of neuroblastoma, the most common solid tumor in children. They identify recurrent somatic mutations in the chromatin-r...
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Article
Archaeology, Memory and Oral Tradition: An Introduction
This paper serves as an introduction to this special edition of the International Journal of Historical Archaeology on the theme of archaeology, memory and oral history. Recent approaches to oral history and memo...
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Article
“Thrown Like Chaff in the Wind”: Excavation, Memory and the Negotiation of Loss in the Scottish Highlands
Memory has become an important area of research in historical archaeology over the last decade with an increasing focus on retrieving the narratives of subaltern groups and painful memories of conflict, displa...
