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Article
Open AccessNCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance
The spatiotemporal regulation of inflammasome activation remains unclear. To examine the mechanism underlying the assembly and regulation of the inflammasome response, here we perform an immunoprecipitation-ma...
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Article
Open AccessDifferent metazoan parasites, different transcriptomic responses, with new insights on parasitic castration by digenetic trematodes in the schistosome vector snail Biomphalaria glabrata
Gastropods of the genus Biomphalaria (Family Planorbidae) are exploited as vectors by Schistosoma mansoni, the most common causative agent of human intestinal schistosomiasis. Using improved genomic resources, ov...
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Article
Sex differences in hemoglobin levels and five-year refracture risk in patients with osteoporotic fractures: a retrospective cohort analysis
We conducted a retrospective cohort analysis to examine the association between hemoglobin (Hb) levels and refracture risk in elderly patients with osteoporotic fractures (OPFs). Our findings suggest a nonline...
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Article
Open AccessProfiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice
Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo ...
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Article
GLP-1RAs inhibit the activation of the NLRP3 inflammasome signaling pathway to regulate mouse renal podocyte pyroptosis
Podocytes are closely related to renal function as an important part of the glomerulus. The reduction and damage of podocytes lead to further decline of renal function and aggravate the progression of DKD. Glu...
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Article
Equilibrium Risk Decision Model for Bidding Electricity Quantity Deviation of Cascade Hydropower Stations
There is a common phenomenon in China where the upstream and downstream hydropower stations of Cascade Hydropower Stations (CHS) belong to different operating entities. When independently participating in mark...
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Article
Open AccessYolk proteins of the schistosomiasis vector snail Biomphalaria glabrata revealed by multi-omics analysis
Vitellogenesis is the most important process in animal reproduction, in which yolk proteins play a vital role. Among multiple yolk protein precursors, vitellogenin (Vtg) is a well-known major yolk protein (MYP...
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Article
Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics
In this paper, we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes equations. That is, t...
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Article
Open AccessIcariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction
Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibr...
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Article
Open AccessAssociation between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures
Few studies have examined the relationship between perioperative blood transfusion (PBT) and length of hospital stay (LOS) in patients with osteoporotic fractures. This research aims to study the association b...
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Article
Open AccessPrognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...
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Article
A numerical study of viscous granular flow in artificial step-pool systems: flow characteristics and structure optimization
Inspired by the geomorphologic phenomenon of step-pool bed configuration, analogous dissipation structures are set in drainage channels to mitigate granular flow hazards. The sensible design of artificial step...
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Article
Open AccessAssociation between serum 25-hydroxyvitamin D and fasting blood glucose in osteoporosis patients
Osteoporosis (OP) is often associated with other complications, such as impaired glucose homeostasis. Vitamin D deficiency is common and has been linked to bone metabolism and the regulation of blood sugar lev...
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Article
Open AccessImpairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including ...
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Article
Open AccessOxidative Stress-Involved Mitophagy of Retinal Pigment Epithelium and Retinal Degenerative Diseases
The retinal pigment epithelium (RPE) is a highly specialized and polarized epithelial cell layer that plays an important role in sustaining the structural and functional integrity of photoreceptors. However, t...
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Article
Establishment and study of a polarized X-ray radiation facility
With the advancement in X-ray astronomical detection technology, various celestial polarization detection projects have been initiated. To meet the calibration requirements of polarimeters on the ground, a pol...
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Article
Open AccessAssociation of 25-hydroxyvitamin D levels with lipid profiles in osteoporosis patients: a retrospective cross-sectional study
In the literature, scarce data investigate the link between 25-hydroxyvitamin D (25[OH]D) and blood lipids in the osteoporosis (OP) population. 25(OH)D, as a calcium-regulating hormone, can inhibit the rise of...
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Article
Nb2CTx MXene boosting PEO polymer electrolyte for all-solid-state Li-S batteries: two birds with one stone strategy to enhance Li+ conductivity and polysulfide adsorptivity
All-solid-state lithium-sulfur (Li-S) battery is regarded as next-generation high energy density and safety battery system. The key challenge is to develop a compatible high-performance solid-state electrolyte...
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Article
Research on the blocking effect of baffle-net structure on rock avalanches: consider the influence of particle splashing
This paper discussed the changes in the movement trajectories and deposition patterns of the rock avalanches in the baffle-net structure under different cases, and obtained the optimal layout parameters of th...
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Article
Open AccessPromotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2
In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing evidence has shown that the external ...
