660 Result(s)

Article

Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS

To investigate the biological activity of human lens epithelial cells (HLEC) in producing inducible nitric oxide synthase (iNOS) and nitric oxide (NO), and to assesse the effect of diethyldithiocarbamate (DDC)...

De-xin Li, Si-ling Wang, Yoshimasa Ito, **g-hai Zhang… in Acta Pharmacologica Sinica (2005)

Article

Pharmacological profiles of an anticholinergic agent, phencynonate hydrochloride, and its optical isomers

To comparatively study the pharmacological profiles of 3-methyl-3-azabicyclo (3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (phencynonate hydrochloride, CPG), an anticholinergic agent, and its enanti...

Li-yun Wang, Yun Wang, Jian-quan Zheng, Bo-hua Zhong, He Liu… in Acta Pharmacologica Sinica (2005)

Article

Neocartilage formation from predifferentiated human adipose derived stem cells in vivo

To examine the chondrogenic potential of human adipose derived stem cells (hASC) induced by human transforming growth factor beta2 (hTGF beta2) in vitro, and to investigate if predifferentiated hASC can produce n...

**ao-bing **, Yong-sheng Sun, Ke Zhang, **g Wang… in Acta Pharmacologica Sinica (2007)

Article

Detection and identification of enterohemorrhagic Escherichia coli O157:H7 and Vibrio cholerae O139 using oligonucleotide microarray

The rapid and accurate detection and identification of the new subtype of the pathogens is crucial for diagnosis, treatment and control of the contagious disease outbreak. Here, in this study, an approach to d...

Da-Zhi **, **ao-**g Xu, Su-Hong Chen, Si-Yuan Wen… in Infectious Agents and Cancer (2007)

Article

Retrospective study of adenovirus in autopsied pulmonary tissue of pediatric fatal pneumonia in South China

Adenovirus are the important pathogen of pediatric severe pneumonia. The aim of this study is to analyze the infection, subtype and distribution of adenovirus in autopsied pulmonary tissue of fatal pneumonia i...

Zhi-Ying Ou, Qi-Yi Zeng, Feng-Hua Wang, Hui-Min **a, Jun-Peng Lu… in BMC Infectious Diseases (2008)

Article

Identification of a differentially expressed gene, ACL, between Meishan × Large White and Large White × Meishan F1 hybrids and their parents

ATP-citrate lyase (ACL), one of the lipogenic enzymes, catalyses the formation of acetyl-coenzyme A (CoA) involved in the synthesis of fatty acid and cholesterol. In pig, very little is known about the ACL gene. ...

Zhu-Qing Ren, Yan Wang, Yong-Jie Xu, Lin-Jie Wang… in Genetics Selection Evolution (2008)

Article

Efficient discovery of abundant post-translational modifications and spectral pairs using peptide mass and retention time differences

Peptide identification via tandem mass spectrometry is the basic task of current proteomics research. Due to the complexity of mass spectra, the majority of mass spectra cannot be interpreted at present. The e...

Yan Fu, Wei Jia, Zhuang Lu, Haipeng Wang, Zuofei Yuan, Hao Chi… in BMC Bioinformatics (2009)

Article

Erratum to: Study on the purification of polysaccharides from Noscoc flagelliforme with radial flow chromatography

Yu-Jie Dai, **g-Wen Wang, Shi-Ru Jia… in Biotechnology and Bioprocess Engineering (2009)

Article

Hydrogen peroxide stress stimulates phosphorylation of FoxO1 in rat aortic endothelial cells

To examine whether the phosphorylation of the O subfamily of forkhead transcription factors (FoxO) is involved in response to oxidative stress in rat aortic endothelial cells (RAECs).

Ye-yu Wang, Si-min Chen, Hao Li in Acta Pharmacologica Sinica (2010)

Article

Establishment and characterization of a new drug surviving cell line Am1010, derived directly from muscle metastases of a human lung adenocarcinoma patient with multi-drug-resistance to cisplatin, taxol, and gefitinib

To Characterize a new human lung cancer cell line Am1010, derived from drug-surviving cells (DSCs).

Hui-ling Li, Si-ming **e, Liang Zhang, Cheng-jie Cai… in Acta Pharmacologica Sinica (2010)

Article

The Microfloral Analysis of Secondary Caries Biofilm around Class I and Class II Composite and Amalgam Fillings

Secondary caries is responsible for 60 percent of all replacement restorations in the typical dental practice. The diversity of the bacterial sources and the different types of filling materials could play a r...

Si-su Mo, Wei Bao, Guang-yun Lai, Jun Wang, Ming-yu Li in BMC Infectious Diseases (2010)

Article

ISO-1, a Macrophage Migration Inhibitory Factor Antagonist, Inhibits Airway Remodeling in a Murine Model of Chronic Asthma

Airway remodeling is the process of airway structural change that occurs in patients with asthma in response to persistent inflammation and leads to increasing disease severity. Drugs that decrease this persis...

Pei-Fen Chen, Ya-ling Luo, Wei Wang, Jiang-xin Wang, Wen-yan Lai… in Molecular Medicine (2010)

Article

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

Although increasing evidence has indicated that brain insulin dysfunction is a risk factor for Alzheimer disease (AD), the underlying mechanisms by which insulin deficiency may impact the development of AD are...

Xu Wang, Wei Zheng, **g-Wei **e, Tao Wang, Si-Ling Wang… in Molecular Neurodegeneration (2010)

Article

Speeding up tandem mass spectrometry-based database searching by longest common prefix

Tandem mass spectrometry-based database searching has become an important technology for peptide and protein identification. One of the key challenges in database searching is the remarkable increase in comput...

Chen Zhou, Hao Chi, Le-Heng Wang, You Li, Yan-Jie Wu, Yan Fu… in BMC Bioinformatics (2010)

Article

Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation

Some small molecules can induce mouse embryonic stem (ES) cells to differentiate into neuronal cells. Here, we explored the effect of isobavachin (IBA), a compound with a prenyl group at position 8 of ring A, ...

Dan-yin Wang, Yu-zhe Hu, Si-si Kong, Yong-** Yu… in Acta Pharmacologica Sinica (2011)

Article

Huperzine A Activates Wnt/β-Catenin Signaling and Enhances the Nonamyloidogenic Pathway in an Alzheimer Transgenic Mouse Model

Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy. In this study, we searched for new mechani...

Chun-Yan Wang, Wei Zheng, Tao Wang, **g-Wei **e, Si-Ling Wang… in Neuropsychopharmacology (2011)

Article

Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces

To study the metabolic and pharmacokinetic profile of scutellarin, an active component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz, and to investigate the mechanisms underlying the low bioavailab...

Jian-feng **ng, Hai-sheng You, Ya-lin Dong, Jun Lu… in Acta Pharmacologica Sinica (2011)

Article

Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E

Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling tec...

Shen-ye Yu, Wei Peng, Wei Si, Lu Yin, Si-guo Liu, Hui-fang Liu… in Virology Journal (2011)

Article

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct binding sites. Previous studies have reported that g...

Rong-Qing Chen, Shan-Hui Wang, Wen Yao, **g-**g Wang, Fang Ji… in Neuropsychopharmacology (2011)

Article

Evaluation of human enterovirus 71 and coxsackievirus A16 specific immunoglobulin M antibodies for diagnosis of hand-foot-and-mouth disease

Hand-foot-and-mouth disease (HFMD) is caused mainly by the human enterovirus type 71 (HEV71) and the Coxsackievirus A group type 16 (CVA16). Large outbreaks of disease have occurred frequently in the Asia-Paci...

Nan Yu, Min Guo, Si-Jie He, Yu-**an Pan, **n-**n Chen, **-**a Ding… in Virology Journal (2012)