21 Result(s)

Article

PBR1 selectively controls biogenesis of photosynthetic complexes by modulating translation of the large chloroplast gene Ycf1 in Arabidopsis

The biogenesis of photosystem I (PSI), cytochrome b₆f (Cytb₆f) and NADH dehydrogenase (NDH) complexes relies on the spatially and temporally coordinated expression and translation of both nuclear and chloroplast ...

**ao-Fei Yang, Yu-Ting Wang, Si-Ting Chen, Ji-Kai Li, Hong-Tao Shen… in Cell Discovery (2016)

Article

UHRF1 is required for basal stem cell proliferation in response to airway injury

Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for ...

Handan **ang, Lifeng Yuan, **a Gao, Peter B Alexander, Omar Lopez… in Cell Discovery (2017)

Article

Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression

The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH). Here we demonstrated...

Chen-Yi Jiang, Bo-Yu Yang, Sheng Zhao, Si-Hui Shao, **ao-Yu Bei… in Cell Death & Disease (2018)

Article

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy

Autophagy is an endogenous protective process; the loss of autophagy could destabilize proteostasis and elevate intracellular oxidative stress, which is critically involved in the development of cardiac hypert...

Man Xu, Chun-xia Wan, Si-hui Huang, Hui-bo Wang, Di Fan… in Cell Death & Disease (2019)

Article

CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation

Tumor initiating cells (TIC) of lung cancer are mainly induced by stress-related plasticity. Calcium/Calmodulin dependent protein kinase II alpha (CAMK2A) is a key calcium signaling molecule activated by exoge...

Si-Qi Wang, **g Liu, **g Qin, Yun Zhu, Vicky Pui-Chi Tin… in Cell Death & Disease (2020)

Article

MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway

Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite ce...

Kai-Yi Song, **u-Ming Guo, Hui-Qi Wang, Lei Zhang, Si-Yuan Huang… in Cell Death & Disease (2020)

Article

MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex

Neonatal hypoxic–ischemic (HI) injury derived from asphyxia during perinatal period, is a serious complication of neonatal asphyxia and the main cause of neonatal acute death and chronic neurological injury. A...

Zi-Bin Zhang, Liu-Lin **ong, Lu-Lu Xue, Yan-** Deng, Ruo-Lan Du… in Cell Death & Disease (2021)

Article

LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

Maintaining proper mitochondrial respiratory function is crucial for alleviating cardiac metabolic disorders during obesity, and mitophagy is critically involved in this process. Long non-coding RNA H19 (H19) ...

Shao-Hua Wang, **ao-Lin Zhu, Fei Wang, Si-Xu Chen, Zhi-Teng Chen… in Cell Death & Disease (2021)

Article

Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy

One of the best ways to control COVID-19 is vaccination. Among the various SARS-CoV-2 vaccines, inactivated virus vaccines have been widely applied in China and many other countries. To understand the underlyi...

Ming-Liang Ma, Da-Wei Shi, Yang Li, Wei Hong, Dan-Yun Lai, Jun-Biao Xue… in Cell Discovery (2021)

Article

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis

Protein phosphatase 6 (PP6) is a member of the PP2A-like subfamily, which plays significant roles in numerous fundamental biological activities. We found that PPP6C plays important roles in male germ cells rec...

Wen-Long Lei, Yuan-Yuan Li, Tie-Gang Meng, Yan Ning, Si-Min Sun… in Cell Death & Disease (2021)

Article

EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression

Emerging evidence indicates that circRNAs are broadly expressed in osteosarcoma (OS) cells and play a crucial role in OS progression. Recently, cancer-specific circRNA circPRKAR1B has been identified by high-t...

Zhen-hua Feng, Lin Zheng, Teng Yao, Si-yue Tao, **ao-an Wei… in Cell Death & Disease (2021)

Article

Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells

Cervical cancer is the leading cause of cancer-related deaths in women, and treatment for cervical cancer is very limited. Emerging evidence suggests that targeting ferroptosis is a promising way to treat canc...

Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He in Cell Death & Disease (2021)

Article

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment par...

Wen-** Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu… in Cell Death & Disease (2022)

Article

SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7

Recent studies uncovered the emerging roles of SAPCD2 (suppressor anaphase-promoting complex domain containing 2) in several types of human cancer. However, the functions and underlying mechanisms of SAPCD2 in...

Zi-Mu Zhang, Hai-Bo Cao, Zhi-Heng Li, Ran Zhuo, Yan-Fang Tao… in Cell Death & Disease (2022)

Article

Ca²⁺ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca²⁺) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with hu...

Ke-Yan Yang, Song Zhao, Hai** Feng, Jiaqi Shen, Yuwei Chen… in Cell Death & Disease (2022)

Article

Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury

Alterations in phospholipids have long been associated with spinal cord injury (SCI). However, their specific roles and signaling cascades in mediating cell death and tissue repair remain unclear. Here we inve...

Nai-Kui Liu, Ling-**ao Deng, Miao Wang, Qing-Bo Lu, Chunyan Wang… in Cell Death & Disease (2022)

Article

Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma

Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, tr...

Wen-** Chen, Ke-qin Dong, **u-wu Pan, Si-shun Gan, Da Xu… in Cell Death & Disease (2023)

Article

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleoti...

Wei Li, Wang-Sheng Jiang, Ya-Ru Su, Ke-Wu Tu, Lin Zou… in Cell Death & Disease (2023)

Article

Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose

Yuemiao Zhang, Meng-Ting Luo, Qingqin Wu, Yun-**a Wang, Xupu Ma… in Cell Discovery (2023)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)