153 Result(s)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

Mitochondrial dysfunction: mechanisms and advances in therapy

Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in ma...

Yao Zong, Hao Li, Peng Liao, Long Chen, Yao Pan… in Signal Transduction and Targeted Therapy (2024)

Article

A pathological joint–liver axis mediated by matrikine-activated CD4⁺ T cells

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...

Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination cou...

Chuan Yang, Xue** Wang, Kenneth K. W. To… in Signal Transduction and Targeted Therapy (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes

Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key en...

Qing Zhang, Mengen **ng, Zhengkai Bao, Lu Xu… in Signal Transduction and Targeted Therapy (2024)

Article

Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma

Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue in pancreatic ductal adenocarcinoma (PDAC). PDAC is characterized by a nutrient-deprived...

Ying-Na Liao, Yan-Zhi Gai, Li-Heng Qian, Hong Pan, Yi-Fan Zhang, Pin Li… in Oncogenesis (2024)

Article

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptid...

**nyi Yang, Xu Zheng, Yuqi Zhu, **aying Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits, and this process requires the proper recruitment of adaptor ...

Yan Guo, Pan **ang, **aojiao Sun, Wei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment

Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that can bind to several receptors and mediate distinct molecular pathways in various cell settings. Changing levels of LECT2 have been...

Chin-Jui Wu, Ke-Fan Pan, Ji-Qing Chen, Yu -Chen Tao, Yu-Cheng Liu, Bo-Rong Chen… in Oncogene (2024)

Article

LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α

Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ubiquitin ligase capable of catalyzing prot...

Ying **, Yazhi Peng, Jie Xu, Ye Yuan, Nan Yang, Zemei Zhang, Lei Xu, Lin Li… in Oncogenesis (2024)

Article

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms ...

Lei Zhang, Jiabing Chen, **aoying Yang… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

Meina Wang, Kaili Long, Enjie Li, Lulu Li, Binghua Li, Shusheng Ci, Lingfeng He… in Oncogene (2024)

Article

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in ...

You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

**a Xu, Tao Yu, Lingling Dong, Rainer Glauben… in Signal Transduction and Targeted Therapy (2023)

Article

S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway

Cell senescence deters the activation of various oncogenes. Induction of senescence is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate rec...

Yi-** Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-**a Wang, Yu-**n Hua, Han-Yin Hu… in Oncogene (2023)

Article

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement...

**a Xu, Tao Yu, Lingling Dong, Rainer Glauben… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals

Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T_FH) cells. H...

Rongzhang He, **ngyu Zheng, Jian Zhang, Bo Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis

Tianli Chen, Hongda Liu, Zengli Liu, Kangshuai Li, Ruixi Qin, Yue Wang… in Oncogene (2023)