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Article
Open AccessEpidemiology and analysis of SARS-CoV-2 Omicron subvariants BA.1 and 2 in Taiwan
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in October 2021, possessed many mutations compared to previous variants. We aimed to identify and analyze SAR...
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Article
Open AccessAryl hydrocarbon receptor–kynurenine axis promotes oncogenic activity in BCP-ALL
B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common childhood cancer, originates from lymphoid precursor cells in bone marrow committed to the B-cell lineage. Environmental factors and gen...
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Article
Open AccessTIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial–mesenchymal transition and metastasis in liver cancer
Metastasis is the main cause of cancer mortality. However, the triggering mechanisms and regulation of epithelial–mesenchymal transition (EMT) factors in the commitment of metastasis have not been well charact...
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Article
Atypical teratoid/rhabdoid tumor of lumbar spine in a toddler child
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare pediatric central nervous system malignancy with poor outcome. AT/RT is infrequently located in the spinal cord.
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Article
Watermark design based on Steiner triple systems
Constructing a set of watermarks of a specific structure may be one requirement for robust watermarking. This study aims to use the structure of Steiner triple systems to generate new watermarks. That is, the ...
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Article
Genoty** of intron 22 inversion of factor VIII gene for diagnosis of hemophilia A by inverse-shifting polymerase chain reaction and capillary electrophoresis
This is the first capillary electrophoresis (CE) analysis for diagnosis of hemophilia A (HA). The intron 22 inversion of factor VIII gene (F8) causes 40–50 % of severe bleeding disorder of HA in all human popu...
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Article
Posterior reversible encephalopathy syndrome in critically ill children: a case series
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Article
Open AccessLow penetrance of retinoblastoma for p.V654L mutation of the RB1 gene
Retinoblastoma is caused by compound heterozygosity or homozygosity of retinoblastoma gene (RB1) mutations. In germline retinoblastoma, mutations in the RB1 gene predispose individuals to increased cancer risks d...
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Article
Health-related quality of life and cognitive outcomes among child and adolescent survivors of leukemia
Long-term survival of childhood leukemia has become a reality with treatment advancement; hence, the need to assess the survivors’ health-related quality of life (HRQL) is essential. Although a growing number ...
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Article
Analysis of methotrexate and its eight metabolites in cerebrospinal fluid by solid-phase extraction and triple-stacking capillary electrophoresis
We establish a triple-stacking capillary electrophoresis (CE) separation method to monitor methotrexate (MTX) and its eight metabolites in cerebrospinal fluid (CSF). Three stacking methods with different mecha...
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Article
Life-threatening airway obstruction caused by penicilliosis in a leukemic patient
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Article
Open AccessMutation spectrum of 122 hemophilia A families from Taiwanese population by LD-PCR, DHPLC, multiplex PCR and evaluating the clinical application of HRM
Hemophilia A represents the most common and severe inherited hemorrhagic disorder. It is caused by mutations in the F8 gene, which leads to a deficiency or dysfunctional factor VIII protein, an essential cofac...
