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Article
Open AccessHypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair
The challenges posed by delayed atrophic healing and nonunion stand as formidable obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and osteogenesis emerge as pivotal mechanism...
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Article
Evaluation for the effect of low-carbon city pilot policy: evidence from industry in China
The investigation of the implementation effect of the low-carbon city pilot (LCCP) policy in promoting industrial low-carbon development is important for economic growth and carbon reduction in China. This pap...
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Article
Effect of Induction Quenching and Tempering Temperature on the Mechanical Properties and Microstructure Evolution of 45 Steel for Linear Guide
In this paper, the influence of induction quenching and tempering temperatures on the evolution of mechanical properties and microstructure of 45 steel for linear guides were investigated based on the tensile,...
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Article
Open AccessA case study of combined neoadjuvant chemotherapy and neoadjuvant immunotherapy in resectable locally advanced esophageal cancer
The prognosis of patients under existing neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy requires improvement. Whereas programmed cell death 1 (PD-1) inhibitors have shown promising response in advan...
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Article
Components Analysis of Recycled Alkali Black Liquor Combined with Corn Straw Under Ozone Pretreatment
Alkali combined with ozone pretreatment of corn straw could improve the enzymatic hydrolysis degree of cellulose to realize the biomass conversion of straw waste. In order to recycle the alkali black liquor de...
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Article
Open AccessCDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown.
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Article
Open AccessTROAP switches DYRK1 activity to drive hepatocellular carcinoma progression
Hepatocellular carcinoma (HCC) is one of the common malignancy and lacks effective therapeutic targets. Here, we demonstrated that ectopic expression of trophinin-associated protein (TROAP) dramatically drove ...
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Article
Open AccessPIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway
Inflammatory factors and activation of oncogenes both played critical roles in the development and progression of human hepatocellular carcinoma (HCC). However, the interplay between these two has not been wel...
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Article
HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies and lacks targeted therapies. Here, we reported a novel potential therapeutic target hematological and neurological expressed 1 like (HN1L
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Article
Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway
The poorly differentiated hepatocellular carcinoma (HCC) cells are usually characterized by immature hepatic progenitor cell-like properties, such as enhanced self-renewal ability, resistance to chemotherapeut...
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Article
Construction of a plasmid for overexpression of human circadian gene period2 and its biological activity in osteosarcoma cells
Beyond their established role in the mammalian circadian clock, recent studies have confirmed that the circadian genes have been implicated in tumor onset and progression. Currently, the biological effects of ...
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Article
Application of fast-responding pressure-sensitive paint to a hemispherical dome in unsteady transonic flow
The current work focuses on the development and application of fast-responding polymer/ceramic pressure-sensitive paint (PSP) as an advanced surface pressure measurement technique for unsteady flow fields in l...
