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  1. Article

    Open Access

    A machine learning approach to personalized dose adjustment of lamotrigine using noninvasive clinical parameters

    The pharmacokinetic variability of lamotrigine (LTG) plays a significant role in its dosing requirements. Our goal here was to use noninvasive clinical parameters to predict the dose-adjusted concentrations (C...

    **uqing Zhu, Wencan Huang, Haoyang Lu, Zhanzhang Wang, **aojia Ni… in Scientific Reports (2021)

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  2. No Access

    Article

    Energy-saving traffic scheduling in backbone networks with software-defined networks

    The rapid development of communications networks facilitate our lives but bring severe energy consumption problems. As an emerging network structure, software-defined networking can realize flexible scheduling...

    Junru Lei, Shuhua Deng, Zebin Lu, Yihao He, ** Gao in Cluster Computing (2021)

  3. No Access

    Article

    Synthesis, Stability and Direct Antiproliferative Effect of New Cysteine Modified GnRH Analogs

    It is demonstrated that gonadotropin-releasing hormone (GnRH) analogs can directly inhibit the proliferation of reproductive tissue cancer cells, but the poor pharmacokinetic properties still restrict their ap...

    Songtao Li, Hongling Zhao, Ruxing Wang… in International Journal of Peptide Research … (2019)

  4. No Access

    Article

    Liquid L-thyroxine versus tablet L-thyroxine in patients on L- thyroxine replacement or suppressive therapy: a meta-analysis

    To compare the effectiveness of liquid L-T4 (L-thyroxine) and tablet L-T4 in patients on L-T4 replacement or suppressive therapy.

    Irakoze Laurent, Siying Tang, Manirakiza Astère, Kan Ran Wang, Shuhua Deng… in Endocrine (2018)

  5. Article

    Open Access

    Effectiveness of advanced carbohydrate counting in type 1 diabetes mellitus: a systematic review and meta-analysis

    Potential benefits of carbohydrate counting for glycemic control in patients with type 1 diabetes mellitus (T1DM) remain inconclusive. Our aim is to systematically assess the efficacy of carbohydrate counting ...

    Shimin Fu, Linjun Li, Shuhua Deng, Li** Zan, Zhi** Liu in Scientific Reports (2016)

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  6. No Access

    Article

    Efficacy, Pharmacokinetics, and Biodistribution of Thermosensitive Chitosan/β-Glycerophosphate Hydrogel Loaded with Docetaxel

    Docetaxel (DTX) is a widely used anticancer drug for various solid tumors. However, its poor solubility in water and lack of specification are two limitations for clinical use. The aim of the study was to deve...

    Cuiyun Li, Shuangxia Ren, Yu Dai, Fengjie Tian, **n Wang, Sufeng Zhou… in AAPS PharmSciTech (2014)

  7. No Access

    Article

    Effects of Dietary Factors on the Pharmacokinetics of 58Fe-labeled Hemin After Oral Administration in Normal Rats and the Iron-deficient Rats

    Hemin, iron (III) protoporphyrin chloride (IX), as a stable form of heme iron, has been used in iron absorption studies. The aim of the present study was to elucidate the influences of body iron status and thr...

    Yongjie Zhang, Di Zhao, Jie Xu, Chunxiang Xu, Can Dong… in Biological Trace Element Research (2013)