22 Result(s)

Article

Smad3-related miRNAs regulated oncogenic TRIB2 promoter activity to effectively suppress lung adenocarcinoma growth

MicroRNAs (miRNAs) and Smad3, as key transcription factors in transforming growth factor-β1 (TGF-β1) signaling, help regulate various physiological and pathological processes. We investigated the roles of Smad3-r...

Yan-**a Zhang, Yun-Fei Yan, Yue-Mei Liu, You-Jie Li, Han-Han Zhang… in Cell Death & Disease (2016)

Article

The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma

Increasing evidence has emerged to suggest that N-myc downstream-regulated gene 2 (NDRG2) dysregulation participates in a number of tumor biological processes. However, the role of NDRG2 and miRNA-mediated NDR...

Yu Wang, Chun-ye Zhang, Rong-hui **a, **g Han, Bao Sun… in Cell Death & Disease (2018)

Article

“In front of patients, I will always be a pupil.” Dr. **aoqian Zhang: the founder of the modern Chinese gastroenterology

Lu Wang, Xudong Liu, Wenli Duan, Shu-yang Zhang in Protein & Cell (2019)

Article

RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2020)

Article

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma

Steroid 5α-reductase type I (SRD5A1) is a validated oncogene in many sex hormone-related cancers, but its role in multiple myeloma (MM) remains unknown. Based on gene expression profiling (GEP) of sequential M...

Renjie Dou, **jun Qian, Wei Wu, Yanxin Zhang, Yuxia Yuan… in Cell Death & Disease (2021)

Article

miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decap** enzyme 2 to promote lung carcinoma proliferation

Non-coding RNAs (ncRNAs) involve in diverse biological processes by post-transcriptional regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a significant role in the development of no...

Qian Zhang, Yun-Fei Yan, Qing Lv, You-Jie Li, Ran-Ran Wang… in Cell Death & Disease (2021)

Article

RvD1 accelerates the resolution of inflammation by promoting apoptosis of the recruited macrophages via the ALX/FasL-FasR/caspase-3 signaling pathway

The uncontrolled inflammatory response caused by a disorder in inflammation resolution is one of the reasons for acute respiratory distress syndrome (ARDS). The macrophage pool markedly expands when inflammato...

Shu-yang **ang, Yang Ye, Qian Yang, Hao- ran Xu, Chen-xi Shen… in Cell Death Discovery (2021)

Article

Glucose-regulated protein 78 modulates cell growth, epithelial–mesenchymal transition, and oxidative stress in the hyperplastic prostate

Benign prostatic hyperplasia (BPH) is a chronic condition which mainly affects elderly males. Existing scientific evidences have not completely revealed the pathogenesis of BPH. Glucose-regulated protein 78 (G...

Xun Fu, Jianmin Liu, Daoquan Liu, Yongying Zhou, Yuhang Guo… in Cell Death & Disease (2022)

Article

Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession

PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 is considered as a “pseudokinase”, contributing to different kinds of can...

Yuan-Rong Liu, Dan-Dan Song, Dong-Min Liang, You-Jie Li… in Cell Death Discovery (2022)

Article

Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2022)

Article

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m⁶A-dependent manner

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...

Li-Jie Chen, Hui-Ye Liu, Zhi-Yuan **ao, Ting Qiu, Dan Zhang… in Cell Death & Disease (2023)

Article

SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not all, forms of chronic kidney disease. In kidneys that are obstructed, specific deletion of Sirt2 in renal tubule epi...

Shu Yang, Guangyan Yang, **nyu Wang, Jiaqing **ang, Lin Kang… in Cell Death & Disease (2023)

Article

Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis

Metabolic reprogramming to glycolysis is closely associated with the development of chronic kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a rate-limiting enzyme in gly...

Shu Yang, Han Wu, Yanchun Li, Lixin Li, Jiaqing **ang, Lin Kang… in Cell Death & Disease (2023)

Article

APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation

The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...

Dan Zhang, Qi-Qi Ni, Shu-Yang Wang, Wen-Feng He… in Cellular and Molecular Life Sciences (2024)