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  1. Article

    Open Access

    Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

    Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer is unknown. CEP inhibited the cellula...

    Yang-yang Lu, Chun-yang Zhu, Yi-xin Ding, Bing Wang, Shu-fen Zhao… in Cell Death Discovery (2023)

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  2. No Access

    Article

    Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis

    Retinoic-acid-receptor-related orphan receptor γ (RORγ) is a major transcription factor for proinflammatory IL-17A production. Here, we revealed that the RORγ deficiency protects mice from STZ-induced Type 1 d...

    Si-yu Tian, Shu-ming Chen, Yong-yi Feng, Jia-ling He, Yong Li in Acta Pharmacologica Sinica (2023)

  3. No Access

    Article

    FXR: structures, biology, and drug development for NASH and fibrosis diseases

    The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid, glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity, type 2 diabetes, nonalcoholic f...

    Si-yu Tian, Shu-ming Chen, Cheng-xi Pan, Yong Li in Acta Pharmacologica Sinica (2022)

  4. No Access

    Article

    Comparison of D-flip-flops and D-latches: influence on SET susceptibility of the clock distribution network

    As technology scales down, clock distribution networks (CDNs) in integrated circuits (ICs) are becoming increasingly sensitive to single-event transients (SETs). The SET occurring in the CDN can even lead to f...

    Pei-Pei Hao, Shu-Ming Chen in Nuclear Science and Techniques (2019)

  5. No Access

    Article

    Analysis of single-event transient sensitivity in fully depleted silicon-on-insulator MOSFETs

    Based on 3D-TCAD simulations, single-event transient (SET) effects and charge collection mechanisms in fully depleted silicon-on-insulator (FDSOI) transistors are investigated. This work presents a comparison ...

    **g-Yan Xu, Shu-Ming Chen, Rui-Qiang Song, Zhen-Yu Wu… in Nuclear Science and Techniques (2018)

  6. No Access

    Article

    Effect of N-fertilizer application on return flow water quality from a terraced paddy field in Northern Taiwan

    Intensive use of chemical fertilizer for crops may be responsible for nitrogen and phosphate accumulation in both groundwater and surface waters. The return flow polluted by nutrients not only results in the l...

    Shih-Kai Chen, Cheng-Shin Jang, Shu-Ming Chen, Kun-Hung Chen in Paddy and Water Environment (2013)

  7. No Access

    Article

    YHFT-QDSP: High-Performance Heterogeneous Multi-Core DSP

    Multi-core architectures are widely used to enhance the microprocessor performance within a limited increase in time-to-market and power consumption of the chips. Toward the application of high-density data si...

    Shu-Ming Chen, Jiang-Hua Wan, Jian-Zhuang Lu… in Journal of Computer Science and Technology (2010)

  8. No Access

    Article

    Zinc Deficiency Increases Platelet Oxidative Stress in Nephrectomized Rats

    We previously reported that reduced platelet endogenous antioxidant enzymes activities are related to the low plasma zinc level in patients with end-stage renal failure (ESRF). In this study, we attempt to eva...

    Shu-Ming Chen, Cheng-Deng Kuo, Low-Tone Ho… in Biological Trace Element Research (2007)

  9. No Access

    Article

    Fluorophotometric Determination of Chlorine Dioxide with Chromotropic Acid

    Trace amounts of chlorine dioxide in water were detected by a fluorophotometric method that was based on the quenching of fluorescence of chromotropic acid (CA). The interference by various ions in the determi...

    Takaho Watanabe, Chang Qing Lin, Shu Ming Chen, Yoshihiro Yoshimura… in Analytical Sciences (1992)