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  1. No Access

    Article

    Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs

    NSC 743400 is a novel synthetic indenoisoquinoline analog under development as an anticancer agent. It is a potent topoisomerase I inhibitor with potential therapeutic advantages over FDA-approved camptothecin...

    Miguel Muzzio, Shu-Chieh Hu, Julianne L. Holleran… in Cancer Chemotherapy and Pharmacology (2015)

  2. No Access

    Article

    Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys

    SR13668 (2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole), is a new candidate cancer chemopreventive agent under development. It was designed using computational modeling based on a naturally o...

    Izet M. Kapetanovic, Miguel Muzzio, Shu-Chieh Hu… in Cancer Chemotherapy and Pharmacology (2010)