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5 Result(s)

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  1. No Access

    Article

    Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

    Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and...

    **nyu Shu, Ning Li, Yi Wu, Wang Li, **aoyu Zhang, Peiwen Li… in Acta Mechanica Sinica (2021)

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    Article

    Flow field analyses of a porous membrane-separated, double-layered microfluidic chip for cell co-culture

    Organs-on-chips composed of a porous membrane-separated, double-layered channels are used widely in elucidating the effects of cell co-culture and flow shear on biological functions. While the diversity of cha...

    Shenbao Chen, Jian Xue, **rong Hu, Qihan Ding, Lüwen Zhou… in Acta Mechanica Sinica (2020)

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    Article

    Flow dynamics analyses of pathophysiological liver lobules using porous media theory

    Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the...

    **rong Hu, Shouqin Lü, Shiliang Feng, Mian Long in Acta Mechanica Sinica (2017)

  4. No Access

    Article

    Mechanokinetics of receptor–ligand interactions in cell adhesion

    Receptor–ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting...

    Ning Li, Shouqin Lü, Yan Zhang, Mian Long in Acta Mechanica Sinica (2015)

  5. No Access

    Article

    Probe stiffness regulates receptor-ligand bond lifetime under force

    Receptor-ligand bond dissociation under applied force is crucial to elucidate its biological functionality when the molecular bond is usually connected to a mechanical probe. While the impact of probe stiffness,

    Yan Zhang, ShouQin Lü, Mian Long in Science China Physics, Mechanics and Astronomy (2011)