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Article
Open AccessGlobal map** of live cell mechanical features using PeakForce QNM AFM
Atomic force microscopy (AFM) has been widely used to acquire surface topography upon different scanning modes and to quantify mechanical properties of a cell using single-point ramp force mode. However, these...
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Article
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness
Directional neutrophil migration during human immune responses is a highly coordinated process regulated by both biochemical and biomechanical environments. In this paper, we developed an integrative mathemati...
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Article
Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector
Translocation of dense nucleus along gravity vector initiates mechanical remodeling of a eukaryotic cell. In our previous experiments, we quantified the impact of gravity vector on cell remodeling by placing a...
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Chapter and Conference Paper
Distinct Kinetics Features of LFA-1 and Mac-1 in Neutrophil Activation
LFA-1 and Mac-1, two β 2 integrin members constitutively expressed on neutrophils, mediate leukocyte recruitment cascade by binding to the same ligand of ICAM-1. The slow rolling and firm adhesion o...