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Open AccessIdentification of the Conformational transition pathway in PIP2 Opening Kir Channels
The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2 regulates Kir channels remains obscure. Here, we performed a series of Targe...
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Article
Forced extension of P-selectin construct using steered molecular dynamics
P-selectin, a 70-nm-long cellular adhesive molecule, possesses elastic and extensible properties when neutrophils roll over the activated endotheliam of blood vessel in inflammatory reaction. Transient formati...