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Article
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and...
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Article
Flow field analyses of a porous membrane-separated, double-layered microfluidic chip for cell co-culture
Organs-on-chips composed of a porous membrane-separated, double-layered channels are used widely in elucidating the effects of cell co-culture and flow shear on biological functions. While the diversity of cha...
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Article
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness
Directional neutrophil migration during human immune responses is a highly coordinated process regulated by both biochemical and biomechanical environments. In this paper, we developed an integrative mathemati...
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Article
Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector
Translocation of dense nucleus along gravity vector initiates mechanical remodeling of a eukaryotic cell. In our previous experiments, we quantified the impact of gravity vector on cell remodeling by placing a...
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Article
Flow dynamics analyses of pathophysiological liver lobules using porous media theory
Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the...
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Article
Mechanokinetics of receptor–ligand interactions in cell adhesion
Receptor–ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting...
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Chapter and Conference Paper
Distinct Kinetics Features of LFA-1 and Mac-1 in Neutrophil Activation
LFA-1 and Mac-1, two β 2 integrin members constitutively expressed on neutrophils, mediate leukocyte recruitment cascade by binding to the same ligand of ICAM-1. The slow rolling and firm adhesion o...