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Article
Open AccessAssociation between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic ...
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Article
Open AccessMiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line
MiRNAs are a group of multifunctional non-coding RNAs which play an important role in the various physiological processes including the development of NAFLD. Recent studies have shown that miR-30b-5p tightly a...
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Article
Open AccessIndependent and joint correlation of PNPLA3 I148M and TM6SF2 E167K variants with the risk of coronary heart disease in patients with non-alcoholic fatty liver disease
CHD is reported to be the primary cause of death in patients with NAFLD. Genetic susceptibility genes contribute to the developmental risk of NAFLD or CHD. Whether the genetic factors could affect the risk of ...
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Article
Open AccessTRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population
Present evidences suggested that TRIB1 rs17321515 polymorphism was tightly associated with the increased risk of NAFLD and CHD. CHD is one of the main complications of NAFLD, whether TRIB1 rs17321515 polymorphism...
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Article
Open AccessTRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population
Dysregulation of the lipid homeostasis is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies had demonstrated that TRIB1 gene polymorphisms affect the plasma lipids metabolism,...
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Article
Open AccessCombining I148M and E167K variants to improve risk prediction for nonalcoholic fatty liver disease in Qingdao Han population, China
PNPLA3 I148M variant and TM6SF2 E167K variant are recognized as the major genetic modifiers of nonalcoholic fatty liver disease (NAFLD). The present study sought to evaluate the potential additive effect of the t...
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Article
Open AccessThe systemic immune-inflammation index is an independent predictor of survival for metastatic colorectal cancer and its association with the lymphocytic response to the tumor
Systemic inflammation and immune dysfunction has been proved to be significantly associated with cancer progression and metastasis in many cancer types, including colorectal cancer. We examined the prognostic ...
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Article
Open AccessComparison of immunological characteristics between paired mismatch repair-proficient and -deficient colorectal cancer patients
Currently, mismatch repair-deficient (dMMR) status is a promising candidate for targeted immune checkpoint inhibition therapy in colorectal cancer (CRC) patients, however, the potential immunological mechanism...
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Article
Derivatives and differentials for multiplicative intuitionistic fuzzy information
By using the unsymmetrical scale instead of the symmetrical scale, the multiplicative intuitionistic fuzzy sets (MIFSs) reflect our intuition more objectively. Each element in a MIFS is expressed by an ordered...
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Article
Zebrafish phosvitin-derived peptide Pt5 inhibits melanogenesis via cAMP pathway
Zebrafish phosvitin-derived peptide Pt5, consisting of the C-terminal 55 residues of phosvitin, has been shown to have an antimicrobial-immunomodulatory activity comparable to phosvitin. Here, we showed clearl...
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Article
Open AccessCelecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder. Tyrosine kinase inhibitors (TKIs) are the standard treatments for CML, but a number of patients fail to respond effectively due to gene...
