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  1. Article

    Open Access

    Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1

    The histone H2A variant H2A.W occupies transposons and thus prevents access to them in Arabidopsis thaliana. H2A.W is deposited by the chromatin remodeler DDM1, which also promotes the accessibility of chromatin ...

    Akihisa Osakabe, Yoshimasa Takizawa, Naoki Horikoshi… in Nature Communications (2024)

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  2. Article

    Author Correction: Chromatin integration labeling for map** DNA-binding proteins and modifications with low input

    Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato… in Nature Protocols (2024)

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  3. No Access

    Article

    Chromatin integration labeling for map** DNA-binding proteins and modifications with low input

    Cell identity is determined by the selective activation or silencing of specific genes via transcription factor binding and epigenetic modifications on the genome. Chromatin immunoprecipitation (ChIP) has been...

    Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato… in Nature Protocols (2020)

  4. Article

    Open Access

    Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA

    The N-methyl-D-aspartate (NMDA) receptor has been implicated in several neurodegenerative diseases, including stroke. Low-density lipoprotein receptor-related protein 1 (LRP1) plays pivotal roles in endocytosis a...

    Mariko Yamada, Hideki Hayashi, Kaori Suzuki, Shoko Sato… in Scientific Reports (2019)

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  5. No Access

    Article

    Rolipram plus Sivelestat inhibits bone marrow-derived leukocytic lung recruitment after cardiopulmonary bypass in a primate model

    Cardiopulmonary bypass (CPB) recovery is complicated by lung inflammation from bone marrow (BM)-derived polymorphonuclear leukocytes (PMNs) and monocytes (MO). Although Sivelestat reduces inflammatory mediator...

    Yukinobu Goto, Yuji Hiramatsu, Naohide Ageyama, Shoko Sato… in Journal of Artificial Organs (2019)

  6. No Access

    Article

    Shrinkage temperature and anti-calcification property of triglycidylamine-crosslinked autologous tissue

    Since bioprosthetic valve dysfunction may arise due to histological calcification in the crosslinking process by glutaraldehyde (GA), non-GA crosslinking reagents have been investigated. We compared the effica...

    Masataka Sato, Yuji Hiramatsu, Shonosuke Matsushita… in Journal of Artificial Organs (2014)

  7. No Access

    Article

    Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats

    The isoprenoid geranylgeraniol (GGOH) inhibits nuclear factor-kappa B (NF-κB) activation in the liver, yet the mechanism remains unclear. We investigated the modulation and inhibition of lipopolysaccharide (LP...

    Puspo E. Giriwono, Hitoshi Shirakawa, Yusuke Ohsaki… in European Journal of Nutrition (2013)

  8. No Access

    Article

    Aortic valve calcification and increased stiffness of the proximal thoracic ascending aorta: association with left ventricular diastolic dysfunction and early chronic kidney disease

    The aim of this study was to clarify the relationship between the severity of aortic valve calcification (AVC) and stiffness of the proximal thoracic ascending aorta (TAA), and to examine their influence on le...

    Hiroshi Honma, Tadaaki Ohno, Yukichi Tokita… in Journal of Medical Ultrasonics (2011)

  9. No Access

    Article

    A Case of Idiopathic Retinal Vasculitis, Aneurysm, and Neuroretinitis Effectively Treated by Steroid Pulse Therapy

    Futoshi Ishikawa, Hiroshi Ohguro, Shoko Sato… in Japanese Journal of Ophthalmology (2006)