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Article
The Combinatorial Effect of Ad-IL-24 and Ad-HSV-tk/GCV on Tumor Size, Autophagy, and UPR Mechanisms in Multiple Myeloma Mouse Model
Multiple myeloma is a type of malignant neoplasia whose treatment has changed over the past decade. This study aimed to investigate the effects of combination of Adenovector-carrying interleukin-24 and herpes ...
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Article
Polycaprolactone/poly l-lactic acid nanofibrous scaffold improves osteogenic differentiation of the amniotic fluid-derived stem cells
Using stem cells is one of the most important determining factors in repairing lesions using regenerative medicine. Obtaining adult stem cells from patients is a perfect choice, but it is worth noting that the...
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Article
Open AccessCarboxymethyl Chitosan-Functionalized Polyaniline/Polyacrylonitrile Nano-Fibers for Neural Differentiation of Mesenchymal Stem Cells
Electroconductive scaffolds based on polyaniline (PANi)/polyacrylonitrile (PAN) were fabricated and surface-functionalized by carboxymethyl chitosan (CMC) as efficient scaffolds for nerve tissue regeneration. ...
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Article
Development and Characterization of a Novel Single-Chain Antibody Against B-Cell Activating Factor
As a member of the tumor necrosis factor (TNF) superfamily, the B-cell activating factor (BAFF) plays a crucial role in B-cell survival and differentiation. Overexpression of this protein has been closely link...
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Article
Open AccessXanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture
Despite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. Xanthohumol (XN) is known as a bioactive compound that shows an anticancer effect on ca...
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Article
Guiding mesenchymal stem cells differentiation into chondrocytes using sulfated alginate/cold atmospheric plasma modified polycaprolactone nanofibrous scaffold
Using tissue engineering approaches is one of interesting strategies to repair cartilage injuries. This study reports the preparation of surface-modified electrospun polycaprolactone nanofibrous scaffolds with...
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Article
Open AccessAccelerated reconstruction of rat calvaria bone defect using 3D-printed scaffolds coated with hydroxyapatite/bioglass
Self-healing and autologous bone graft of calvaraial defects can be challenging. Therefore, the fabrication of scaffolds for its rapid and effective repair is a promising field of research. This paper provided...
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Article
Open AccessChemical Immobilization of Carboxymethyl Chitosan on Polycaprolactone Nanofibers as Osteochondral Scaffolds
Carboxymethyl chitosan (CMC) as a bio-based osteochondral inductive material was chemically immobilized on the surface of polycaprolactone (PCL) nanofibers to fabricate scaffolds for osteochondral tissue engin...
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Article
Open AccessDesign and evaluation of a skin-on-a-chip pumpless microfluidic device
The development of microfluidic culture technology facilitates the progress of study of cell and tissue biology. This technology expands the understanding of pathological and physiological changes. A skin chip...
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Article
Teriflunomide Loaded SPION Nanoparticles Induced Apoptosis in MDA-MB-231 Breast Cancer Cells
Teriflunomide (TFN), an immunomodulatory drug, has demonstrated cytotoxic effects in recent studies. This potential can be combined with nano-drug delivery to achieve an improved anticancer formulation.
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Article
Mesenchymal stem cells encapsulation in chitosan and carboxymethyl chitosan hydrogels to enhance osteo-differentiation
Recently biomaterials utilized for designing scaffolds in tissue engineering are not cost-effective and eco-friendly. As a result, we design and develop biocompatible and bioactive hydrogels for osteo-tissue r...
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Article
Open AccessErratum to: Cold Atmosphere Plasma Modification on Beta-Carotene-Loaded Nanofibers to Enhance Osteogenic Differentiation
The article Cold Atmosphere Plasma Modification on Beta-Carotene-Loaded Nanofibers to Enhance Osteogenic Differentiation, written by Yasamin Moradi, Seyed Alireza Atyabi, Ali Ghiassadin, Hadi Bakhshi, Shiva Ir...
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Article
Bone Tissue Engineering by Cell-Imprinted Polydimethyl Silicone Surface and β-Carotene: An In Vitro Study
This study aimed to induce osteodifferentiation by cell imprinting and beta-carotene (βC). Adipose-derived mesenchymal stem cells (ADMSCs) were seeded on MG63 cell-imprinted polydimethyl silicone (PDMS) substr...
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Article
miR-106b enhances human mesenchymal stem cell differentiation to spermatogonial stem cells under germ cell profile genes involved in TGF-b signaling pathways
Mesenchymal stem cells can be differentiated into tissue-specific cells. MicroRNAs (miRNAs) regulate the translation of mRNAs involved in the growth and development of a variety of cells, including primordial ...
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Article
Open AccessInduction of apoptosis and cell cycle arrest in colorectal cancer cells by novel anticancer metabolites of Streptomyces sp. 801
Colorectal cancer is the third and most significant cause of death and fourth most common cancer in the world. Chemotherapy can be introduced in the cases of locally or distantly invasive colorectal cancer. In...
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Article
Open AccessEnhanced osteogenic differentiation of stem cells by 3D printed PCL scaffolds coated with collagen and hydroxyapatite
Bone tissue engineering uses various methods and materials to find suitable scaffolds that regenerate lost bone due to disease or injury. Poly(ε-caprolactone) (PCL) can be used in 3D printing for producing b...
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Article
Synergistic effect of cell and molecule - imprinted substrates for bone tissue engineering
The purpose of this research was to investigate the in vitro osteogenic induction of MG-63 cells using topography and collagen protein printed on polydimethyl siloxane (PDMS).
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Article
Open AccessLaponite/amoxicillin-functionalized PLA nanofibrous as osteoinductive and antibacterial scaffolds
In this study, Amoxicillin (AMX) was loaded on laponite (LAP) nanoplates and then immobilized on the surface of electrospun polylactic acid (PLA) nanofibers to fabricate scaffolds with osteoinductive and antib...
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Article
Neuronal differentiation of mesenchymal stem cells by polyvinyl alcohol/Gelatin/crocin and beta-carotene
Nerve tissues are important in coordinating the motions and movements of the body. Nerve tissue repair and regeneration is a slow process that might take a long time and cost a lot of money. As a result, tissu...
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Article
Fe3O4 nanoparticles coated with carboxymethyl chitosan containing curcumin in combination with hyperthermia induced apoptosis in breast cancer cells
Many studies have demonstrated that curcumin has potential anticancer properties. This research aims to study the effect of iron (II, III) oxide (Fe3O4) nanoparticles coated with carboxymethyl chitosan containing...
