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  1. Article

    Open Access

    Systematic literature review of immunoglobulin trends for anti-CD20 monoclonal antibodies in multiple sclerosis

    To exp lore changes in immunoglobulin (Ig) levels for people with relapsing-multiple sclerosis (RMS) treated with ocrelizumab or ofatumumab and the relationship between Ig levels and infections.

    Shiv Saidha, Judith Bell, Sydney Harold, Jose Marcano Belisario in Neurological Sciences (2023)

  2. Article

    Open Access

    Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis

    Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography–angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina...

    Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi in Journal of Neuroinflammation (2023)

  3. No Access

    Chapter and Conference Paper

    Recurrent Self Fusion: Iterative Denoising for Consistent Retinal OCT Segmentation

    Optical coherence tomography (OCT) is a valuable imaging technique in ophthalmology, providing high-resolution, cross-sectional images of the retina for early detection and monitoring of various retinal and ne...

    Shuwen Wei, Yihao Liu, Zhangxing Bian, Yuli Wang in Ophthalmic Medical Image Analysis (2023)

  4. No Access

    Article

    From the prodromal stage of multiple sclerosis to disease prevention

    A prodrome is an early set of signs or symptoms that indicate the onset of a disease before more typical symptoms develop. Prodromal stages are well recognized in some neurological and immune-mediated diseases...

    Ruth Ann Marrie, Mark Allegretta, Lisa F. Barcellos, Bruce Bebo in Nature Reviews Neurology (2022)

  5. No Access

    Chapter and Conference Paper

    Bi-directional Synthesis of Pre- and Post-contrast MRI via Guided Feature Disentanglement

    Magnetic resonance imaging (MRI) with gadolinium contrast is widely used for tissue enhancement and better identification of active lesions and tumors. Recent studies have shown that gadolinium deposition can ...

    Yuan Xue, Blake E. Dewey, Lianrui Zuo in Simulation and Synthesis in Medical Imaging (2022)

  6. Article

    Open Access

    Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis

    Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different ...

    Ioannis N. Petropoulos, Kathryn C. Fitzgerald, Jonathan Oakley in Scientific Reports (2021)

  7. No Access

    Chapter

    Clinical Approach to Autoimmune and Inflammatory Ophthalmologic Disease

    Affliction of the afferent visual system, in particular acute optic neuritis (AON), is commonly seen in multiple sclerosis (MS) and other inflammatory autoimmune conditions. AON is an inflammatory condition of...

    Megan Esch, Shiv Saidha in Neuroimmunology (2021)

  8. No Access

    Article

    Moyamoya masquerading as relapsing remitting multiple sclerosis

    Sydney Feldman, Megan Esch, Shiv Saidha in Neurological Sciences (2019)

  9. No Access

    Chapter and Conference Paper

    Fully Convolutional Boundary Regression for Retina OCT Segmentation

    A major goal of analyzing retinal optical coherence tomography (OCT) images is retinal layer segmentation. Accurate automated algorithms for segmenting smooth continuous layer surfaces, with correct hierarchy ...

    Yufan He, Aaron Carass, Yihao Liu in Medical Image Computing and Computer Assis… (2019)

  10. Article

    Open Access

    Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

    The retinal microcirculation has been studied in various diseases including multiple sclerosis (MS). However, inter-eye correlations and potential differences of the retinal blood flow velocity (BFV) remain la...

    Liang Wang, Ohemaa Kwakyi, James Nguyen, Esther Ogbuokiri, Olwen Murphy in Eye and Vision (2018)

  11. Article

    Open Access

    Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

    To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology.

    Liang Wang, Olwen Murphy, Natalia Gonzalez Caldito, Peter A. Calabresi in Eye and Vision (2018)

  12. No Access

    Chapter and Conference Paper

    Towards Topological Correct Segmentation of Macular OCT from Cascaded FCNs

    Optical coherence tomography (OCT) is used to produce high resolution depth images of the retina and is now the standard of care for in-vivo ophthalmological assessment. In particular, OCT is used to study the ch...

    Yufan He, Aaron Carass, Yeyi Yun, Can Zhao in Fetal, Infant and Ophthalmic Medical Image… (2017)

  13. No Access

    Chapter

    Neuromyelitis optica

    A 45-year-old woman with a history of right-sided optic neuritis (ON) with severe residual vision loss presented with rapidly evolving bilateral lower extremity weakness. She reported that approximately 7 days...

    Elias Sotirchos, Shiv Saidha in Case Studies in Multiple Sclerosis (2017)

  14. No Access

    Article

    In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques

    Macular optical coherence tomography (OCT) segmentation, enabling quantification of retinal axonal and neuronal subpopulations, may help elucidate the neuroretinal pathobiology of multiple sclerosis (MS). This...

    Michaela A. Seigo, Elias S. Sotirchos, Scott Newsome in Journal of Neurology (2012)

  15. No Access

    Article

    Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography

    The aim of this work was to determine if neurosarcoidosis (NS) patients exhibit quantitative and/or qualitative in vivo evidence of retinal abnormalities on optical coherence tomography (OCT). Retinal imaging...

    Christopher Eckstein, Shiv Saidha, Elias S. Sotirchos, Gita Byraiah in Journal of Neurology (2012)

  16. No Access

    Article

    A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis

    Although multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS), it lacks any definitive diagnostic test. Instead, diagnosis of MS primarily depends upon clinical...

    Christopher Eckstein, Shiv Saidha, Michael Levy in Journal of Neurology (2012)

  17. Article

    Open Access

    Facial diplegia and deafness following a fall

    Shiv Saidha, Noel Fanning in International Journal of Emergency Medicine (2010)

  18. No Access

    Article

    Treatment of anti-glutamic acid decarboxylase antibody-associated limbic encephalitis with mycophenolate mofetil

    Shiv Saidha, S. Murphy, A. Ronayne, P. McCarthy, M. J. Hennessy in Journal of Neurology (2010)

  19. Article

    Open Access

    Spectrum of peripheral neuropathies associated with surgical interventions; A neurophysiological assessment

    We hypothesized that a wide range of surgical procedures may be complicated by neuropathies, not just in close proximity but also remote from procedural sites. The aim of this study was to classify post-operat...

    Shiv Saidha, Jennifer Spillane in Journal of Brachial Plexus and Peripheral … (2010)

  20. No Access

    Article

    l-2-Hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration

    Shiv Saidha, Sinead Murphy, Peter McCarthy, Philip D. Mayne in Journal of Neurology (2010)